Hedegaardbrogaard9942

In this review, we present the most recent reports focusing on the involvement of cAMPspecific PDE4, PDE7, and PDE8 in glycemic and inflammatory response controls as well as the potential utility of the PDE inhibitors in the treatment of AD. Besides the results of in vitro and in vivo studies, the review also presents recent reports from clinical trials.Background The overall changes of ocular motility in Graves' orbitopathy (GO) are not easily quantifiable with the methods currently available, especially in clinical studies. The aim of the present study was to calculate parameters that quantify the changes of ocular motility in GO in relation to the Gorman score for diplopia. Methods We studied 100 GO patients (Group 1) and 100 controls (Group 2). We also included 30 patients treated with intravenous methylprednisolone (iv-MP), assessed at baseline and after 12 and 24 weeks (Group 3), and 66 patients submitted to squint surgery, assessed at baseline and after 12 weeks (Group 4). Ocular ductions were measured in four gaze directions by a perimeter arc and were used to calculate a total motility score (TMS) as the sum of ductions in each direction; a biocular TMS (b-TMS) as the sum of the TMS of two eyes; and an asymmetry ratio (AR) as the sum of the differences of the corresponding ductions between the two fellow eyes divided by the mean difference found in controls. Quality of life was accessed by a specific questionnaire (Graves' orbitopathy quality of life [GO-QoL] questionnaire). Results TMS and b-TMS were lower, while AR was higher, in Group 1 compared with controls (p  less then  0.001). In Group 1, TMS and b-TMS were inversely correlated with the Gorman score (p  less then  0.001) and AR was higher in patients with constant diplopia compared with the others (p  less then  0.001). In Group 3, TMS and b-TMS increased after treatment in responders to iv-MP (p  less then  0.001). In Group 4, TMS and b-TMS improved in all patients after surgery (p  less then  0.01), while AR and GO-QoL score improved only in those without residual constant diplopia (p  less then  0.001). Conclusion We describe a quantitative method to assess eye motility dysfunction in any stage of GO to be used as an outcome measure in clinical studies.Language provides cadences of sounds, silences, and movements that bring to light meaning, which in turn transforms human connections, understanding, and knowledge. When coupled with disciplinary knowledge and opportunities to illuminate with simulation, there are opportunities to influence human connectedness, which is meaningful even in times of a pandemic.At times of perceived rapid and significant change, such as the world has experienced with the current COVID-19 pandemic, the unrepeatable ebb and flow of the paradoxical rhythms inherent in humanuniverse patterning seem to come to the forefront of awareness. What was previously known and familiar seemingly disintegrated in the emergence of the unfamiliar experience of a global quarantine. Dihydroartemisinin cell line While difficulties abounded across the discipline of nursing, these challenges created new opportunities for visioning anew in thinking beyond the restrictions of the COVID-19 pandemic. A challenge is presented to nurse administrators and faculty charged with preparing the next generation of nurses to meet the challenges of an unknowable future by thinking beyond the traditional boundaries of classroom and clinic to co-create new ways of living the teaching-learning mission of nurse education programs.The creation, implementation, and ongoing maintenance of a patient-centered health neighborhood are central to care in the 21st century. This neighborhood must adhere to the principles of patient-centered care and rest on the foundation of nursing theory that honors what is important to people and the mission and vision of healthcare clinics and systems. It is important that there is strong leadership to develop, implement, and maintain a patient-centered health neighborhood. In this paper, there is an exploration of the patient-centered health neighborhood and the ways it connects to Parse's unique nursing paradigm, humanbecoming.In this paper the authors explore the impact of loss of a parent to suicide on adolescents in military families using Marcia's identity status theory and the Roy adaptation model (RAM). After describing a brief case study of a 13-year-old boy in a military family who lost his father in this manner, these two theories are applied to better understand his struggle to develop and maintain a healthy identity and adapt to numerous relocations, deployments, and then loss. The military family stressors are seen as weakening the resilience of children in such families, making them more vulnerable to the impact of parent loss. Implications for nurses and other healthcare professionals are discussed.In this article, the author examines fragility and vitality as it relates to the COVID-19 pandemic. Fear and courage are also explored from a humanbecoming paradigm perspective as well as from philosophical perspectives. Humanbecoming inquiries related to these topics are presented along with personal experiences of the author.Resilience is a phenomenon discussed by scholars in many disciplines; it holds similar definitions across the human, social, and physical sciences. It is important to understand the phenomenon from a variety of disciplines. Therefore, the author of this article reviews the existing literature on resilience from the disciplines of psychology, sociology, philosophy, education, and nursing. The three themes that emerged from a thorough review of the existing literature were (a) hardiness strengthens the ability to harness resources, (b) regulatory flexibility fosters positive functioning, and (c) challenges enhance the ability to rebound.Fibromyalgia is a chronic pain disorder characterized by uncertainty in etiology, symptomatology, diagnosis, treatment, and outcome. link2 The high level of illness uncertainty that results from fibromyalgia is a risk factor for maladjustment to illness. A cross-sectional survey design was used to examine the relationships among illness uncertainty, helplessness, and subjective well-being in 138 women with fibromyalgia. Multiple regression analyses were conducted to examine a predictive model for mediation. We found illness uncertainty is negatively associated with subjective well-being and that helplessness strongly influences the impact of illness uncertainty on subjective well-being in women with fibromyalgia.The purpose of this essay is to explore the meanings of the widely used terms compliance and adherence and the less widely used term concordance and to raise questions about the appropriateness of these terms when used to describe individuals' or groups' health-related behaviors. Discussion focuses on how recognition of how the meanings of these terms has uncovered the failure to honor nursing's emphasis on person/patient-centered care due to power imbalances between healthcare providers and patents and the subsequent lack of patient autonomy. Consideration of these problems with existing terms could facilitate identification of a potentially more appropriate term based on the language of a nursing conceptual model and/or theory.This article describes some of the changes occurring with community in the advent of the COVID-19 pandemic. The humanbecoming community change model along with other views on community are presented to address some of the living quality questions and challenges of a community in flux.Living the art of nursing during the challenging times of a pandemic has profound implications for the discipline of nursing. Opportunities and limitations coexist with persons who shelter in place while others continue to practice amid personal risk in institutions where vital healthcare services are provided. This article illustrates potential lessons to be learned for future nurse practice and the ethos or straight-thinking implications for living quality during a global health crisis.The paper consists of reflections on the corona pandemic and nursing knowledge as practice. Nurses have been so appreciated by the public during this time that they are referred to as heroes. The moral injustice of taking nurses who come so willing to serve and not provide protective gear for their practice is addressed.Consideration of the impact of COVID-19 on conducting research studies is the subject of this column. First, it is argued that presence is critical to some qualitative methods and especially for those who use the Parse methods. Second, the use of e-mail, telephone, and videoconferencing is examined in terms of their advantages and disadvantages in relation to obtaining knowledge about a phenomenon of interest.Late-life suicide is a public health issue in the United States, and recent CDC data show that the number of deaths related to suicide in older adults continue to increase. Still, few researchers focus on a theoretical framework for the clinical assessment and care of older adults at risk for suicide. We performed a review and critical analysis of the Tidal Model, using Fawcett and DeSanto-Madeya's framework, to increase our understanding of the clinical presentation of older adults with suicidal ideation and present strategies for caring for this population. The Tidal Model is a well-structured theory with relevant concepts and propositions founded on a highly patient-centered and pragmatic approach that facilitates its application in late-life suicidality. The model provides a framework for nursing and healthcare practice in psychiatry and mental health with goals and boundaries that help promote a better assessment of the clinical picture of older adults with suicidal ideation.Designing learning activities to teach psychomotor skills utilizing the lens of humanbecoming required deep reflection on the principles of structuring meaning, configuring rhythmical patterns, and cotranscending with possibles to bridge the theory-to-practice gap. Teaching essential psychomotor skills presented a challenge when trying to ensure the provision of safe, competent, and compassionate care tailored to the individual's unique experience. There are a wide variety of teaching approaches and strategies available, but few have used a theoretical framework to guide the design of the teaching-learning activities to guide development of these skills. link3 The humanbecoming paradigm and humanbecoming teaching-learning model guided the research, design, and presentation of the teaching-learning activities to encompass the science and performing art of nursing.Bone is a highly vascularized organ, providing structural support to the body, and its development, regeneration, and remodeling depend on the microvascular homeostasis. Loss or impairment of vascular function can develop diseases, such as large bone defects, avascular necrosis, osteoporosis, osteoarthritis, and osteopetrosis. In this review, we summarize how vasculature controls bone development and homeostasis in normal and disease cases. A better understanding of this process will facilitate the development of novel disease treatments that promote bone regeneration and remodeling. Specifically, approaches based on tissue engineering components, such as stem cells and growth factors, have demonstrated the capacity to induce bone microvasculature regeneration and mineralization. This knowledge will have relevant clinical implications for the treatment of bone disorders by developing novel pharmaceutical approaches and bone grafts. Finally, the tissue engineering approaches incorporating vascular components may widely be applied to treat other organ diseases by enhancing their regeneration capacity.