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ns (mainly gas bladder and yolk sac abnormalities), and reduced spontaneous tail movements. Thus, the thyroid system disruption represents a likely hypothesis behind the effects caused by the low environmental concentrations of S-metolachlor, its two metabolites and their mixture. UV filters are a class of emerging contaminants with an annual estimated production of 10,000 tons worldwide that continuously enter aquatic environments. Among UV filters, 4-methylbenzylidenecamphor (4-MBC) is an organic camphor derivative used in the cosmetic industry for its ability to protect the skin against UV, specifically UV B radiation. Individuals of the Japanese clam, Ruditapes philippinarum, were exposed to 4-MBC at environmentally relevant and slightly higher concentrations (nominal 0, 1, 10, 100 μg L-1) using a semi-static exposure system over a 7-days period followed by a 3-days depuration period (total 10 days) where no 4-MBC was added to the tanks. Assessed mortality reached up to 100 % at the highest exposure concentration and a LC50 value of 7.71 μg·L-14-MBC was derived. Environmental risk assessment carried out in a site specific environment, the Cadiz bay in the south of Spain, revealed a potential risk produced by the presence of 4-MBC. Digestive glands tissues were analysed for differential expression of genes encoding proteins involved in the stress response (SOD, MT, GST, EIF1, BCL2, TP53, CAT, 18S, GADPH, GPX, GADD45, THIO9) by RT-qPCR for relative quantification. Results showed that the presence of 4-MBC at environmentally relevant concentrations induced the expression of genes that encode for antioxidant enzymes (GST) and for proteins related to the inhibition of apoptosis (BCL2) and cellular stress (GADD), suggesting a physiological stress response. Despite the widespread use of nanoparticles (NPs), there are still major gaps of knowledge regarding the impact of nanomaterials in the environment and aquatic animals. The present work aimed to study the effects of 7 and 40 nm gold nanoparticles (AuNPs) - citrate and polyvinylpyrrolidone (PVP) coated - on the liver proteome of the estuarine/marine fish gilthead seabream (Sparus aurata). After 96 h, exposure to AuNP elicited alterations on the abundance of 26 proteins, when compared to the control group. AuNPs differentially affected several metabolic pathways in S. aurata liver cells. Among the affected proteins were those related to cytoskeleton and cell structure, gluconeogenesis, amino acids metabolism and several processes related to protein activity (protein synthesis, catabolism, folding and transport). The increased abundance of proteins associated with energy metabolism (ATP synthase subunit beta), stress response (94 kDa glucose-regulated protein) and cytoskeleton structure (actins and tubulins) may represent the first signs of cellular oxidative stress induced by AuNPs. Although higher gold accumulation was found in the liver of S. aurata exposed to 7 nm PVP-AuNPs, the 7 nm cAuNPs were more bioactive, inducing more effects in liver proteome. Gold accumulated more in the spleen than in the other assessed tissues of S. aurata exposed to AuNPs, highlighting its potential role on the elimination of these NPs. Motivated by the growing interest in promoting resilience in first responders and other professionals who face threatening professional circumstances, the current study investigated the effectiveness of offering a short-form mindfulness training (MT) program to firefighters. The overarching question was to determine if psychological and cognitive markers of resilience are bolstered via MT. Firefighters (n = 121) were assigned to an MT program (n = 42), an active-comparison relaxation training program (RT, n = 31), or served as no-training controls (NTC, n = 48). Both the MT and RT programs were contextualized for firefighters and consisted of 4, 2-h training sessions delivered over 4 weeks by the same expert trainer, as well as 10-15 min of daily out-of-class practice. Intent-to-treat analyses revealed a significantly greater increase in psychological resilience from baseline (T1) to post-training (T2) in firefighters who received MT vs. RT or no training. In addition, positive affect and objective attentional task performance demonstrated a greater increase over time (from T1 to T2) with more days per week of out-of-class practice for the MT group but not for the RT group. https://www.selleckchem.com/products/atezolizumab.html These results suggest that MT moreso than RT bolsters markers of resilience in firefighters. This study analyzes emissions pathways and mitigation potentials of greenhouse gases (GHGs), air-pollution and short-lived climate pollutants (SLCPs), while taking mitigation actions for achieving a 2 °C global temperature change limit above pre-industrial levels, so-called "2 °C target." The study evaluates SLCPs (i.e. BC, CH4, tropospheric O3) mitigation scenarios by considering synergies and tradeoffs of various combinations of low-carbon measures and air pollutants control measures. It was found that, even if CO2 emissions pathways in this study are all similar to achieve the 2 °C target, reaching a carbon price at around 400 US$/tCO2eq. in 2050, SLCPs and air pollutants emissions pathways and mitigation potentials are largely influenced by combinations of some key mitigation measures. The maximum mitigation potential reductions of SLCPs (BC, CH4) and air pollutants (NOx, CO, NMVOC, which are precursors of tropospheric O3) in Asia are 89%, 22%, 67%, 37%, and 11% respectively by 2050 compared to the 2010 levels. After considering both direct SLCP reduction effects (i.e. mitigating BC, CH4) and indirect SLCP reduction effects (i.e. mitigating NOx, CO, NMVOC for reducing tropospheric O3 generation and atmospheric CH4 concentration), it can be adjudged that combinations of widespread promotion of renewable energies, drastic electrification in transport, residential and commercial sectors, high biofuel shares in the transport sector, and a certain level of deployment of removal devices would be effective SLCP mitigation scenarios. The application of reclaimed water for agricultural irrigation can effectively reduce the use of freshwater resources including groundwater, addressing the increasingly severe challenge of water shortage. However, reclaimed water irrigation will cause potential pollution risks to groundwater, which needs to be further studied to ensure the safety of reclaimed water irrigation. An integrated quantitative assessment system including the modified DRASTIC model was developed to evaluate the pollution risks caused by reclaimed water irrigation and scientific strategies were offered for the development of reclaimed water irrigation in water shortage areas to avoid groundwater pollution. The groundwater intrinsic vulnerability index, the hazards of the characteristic pollutants, and the groundwater values were quantified to obtain the pollution risks distribution map. In the Beijing plain of north China, the low groundwater pollution risk areas were located in the midstream of Chaobai river baisin, Beiyun river basin, and Yongding river basin, accounting for 48.