Pacepratt2539

Crystallization is a significant procedure in the manufacturing of many pharmaceutical and solid food products. Molibresib In-situ electrical resistance tomography (ERT) is a novel process analytical tool (PAT) to provide a cheap and quick way to test, visualize, and evaluate the progress of crystallization processes. In this work, the spatial accuracy of the nonconductive phantoms in low-conductivity solutions was evaluated. Gauss-Newton, linear back projection, and iterative total variation reconstruction algorithms were used to compare the phantom reconstructions for tap water, industrial-grade saturated sucrose solution, and demineralized water. A cylindrical phantom measuring 10 mm in diameter and a cross-section area of 1.5% of the total beaker area was detected at the center of the beaker. Two phantoms with a 10-mm diameter were visualized separately in noncentral locations. The quantitative evaluations were done for the phantoms with radii ranging from 10 mm to 50 mm in demineralized water. Multiple factors, such as ERT device and sensor development, Finite Element Model (FEM) mesh density and simulations, image reconstruction algorithms, number of iterations, segmentation methods, and morphological image processing methods, were discussed and analyzed to achieve spatial accuracy. The development of ERT imaging modality for the purpose of monitoring crystallization in low-conductivity solutions was performed satisfactorily.Diffuse alveolar hemorrhage (DAH) is a life-threatening pulmonary complication in patients with hematologic malignancies or systemic autoimmune disorders. Pathologic findings show pulmonary capillaritis, bland hemorrhage, diffuse alveolar damage, and hemosiderin-laden macrophages, but in the majority of cases, pathogenesis remains unclear. Despite the severity and high mortality, the current treatment options for DAH remain empirical. Systemic treatment to control inflammatory activity including high-dose corticosteroids, cyclophosphamide, and rituximab and supportive care have been applied, but largely unsuccessful in critical cases. Activated recombinant factor VII (FVIIa) can achieve rapid local hemostasis and has been administered either systemically or intrapulmonary for the treatment of DAH. However, there is no randomized controlled study to evaluate the efficacy and safety, and the use of FVIIa for DAH remains open to debate. This review discusses the pathogenesis, diverse etiologies causing DAH, diagnosis, and treatments focusing on hemostasis using FVIIa. In addition, the risks and benefits of the off-label use of FVIIa in pediatric patients will be discussed in detail.For the selective paste intrusion (SPI) method, thin layers of aggregate are locally bound by cement paste where the structure shall arise. After completion of the printing process, the structure is excavated from the particle-bed and the unbound particles are removed. However, for a sufficient layer bonding and shape accuracy, the rheology of the cement paste must be adapted to the flow resistance of the particle-bed. For practical application, that means mostly time and material consuming "trial and error" tests. To prevent that, analytical models can help to predict the penetration of the cement paste. This paper presents four analytical models to calculate the penetration depth of a cement paste into a particle packing. Based on Darcy's law, an already existing model is slightly modified (model A+) and a generalized (model C), an advanced generalized (model D) as well as a simplified model (model B/B+) are developed. Compared to conducted tests on the penetration depth, model B showed good accuracy (deviation less then 1.5 mm) for pastes with a yield stress ≥8.2 Pa, model A+/B+/C for ≥ 5.4 Pa and model D even for less then 5.4 Pa. Finally, an application guide for each model for practical use will be given.Service-learning (SL) is the subject of a growing number of studies and is becoming increasingly popular in physical education teacher education (PETE) programs. The objective of this study was to conduct a systematic review of the implementation of SL programs with PETE students. The databases used were Web of Science, SPORTDiscus (EBSCO), and SCOPUS. Articles were selected on the basis of the following criteria (a) published in a peer-reviewed journal; (b) covers the use of SL programs with PETE students; (c) relates to physical education or physical activity programs; (d) availability of a full-text version in English and/or Spanish. Thirty-two articles met the inclusion criteria. Two types of findings were observed firstly, findings relating to the study characteristics and objectives and, secondly, recommendations for improvement of this type of intervention. The objectives of the different studies focused on (a) the impact of the SL methodology on PETE students' professional, social, and personal skills; (b) its impact on the community; (c) analysis of the effectiveness and quality of the programs. All but two studies analyzed the impact of SL on PETE, while only four analyzed community participants and only three analyzed the quality of the SL program. Recommendations for improving SL programs used with PETE students included all stakeholders, e.g., students and community participants, should be studied and coordinated; the quality of the programs should be assessed, as studying the effectiveness of SL programs could help to attain the objectives of both students and the community; mixed methods should be used; and intervention implementation periods should be extended to provide more objective, controlled measurements.Filarial worms cause multiple debilitating diseases in millions of people worldwide, including river blindness. Currently available drugs reduce transmission by killing larvae (microfilariae), but there are no effective cures targeting the adult parasites (macrofilaricides) which survive and reproduce in the host for very long periods. To identify effective macrofilaricides, we carried out phenotypic screening of a library of 2121 approved drugs for clinical use against adult Brugia pahangi and prioritized the hits for further studies by integrating those results with a computational prioritization of drugs and associated targets. This resulted in the identification of 18 hits with anti-macrofilaricidal activity, of which two classes, azoles and aspartic protease inhibitors, were further expanded upon. Follow up screening against Onchocerca spp. (adult Onchocerca ochengi and pre-adult O. volvulus) confirmed activity for 13 drugs (the majority having IC50 less then 10 μM), and a counter screen of a subset against L.