Mcphersonsalomonsen9726

The sorption performance was better under acidic conditions due to enhanced electrostatic attraction. Humic acid (HA) and PO43- inhibited the sorption through competing for sorption sites, while Fe3+ promoted sorption due to formation of additional FeOAs complexes on sorbent surface. The experimental observations, spectroscopic insights, and density functional theory (DFT) calculations consistently indicate that the sorption of aromatic organoarsenicals on the flower-like CoFe2O4 particles occurs mainly through formation of inner-sphere complexes. The flower-like CoFe2O4 could be regenerated and reused over multiple cycles. The high sorption capacities, together with its magnetic property, make the flower-like CoFe2O4 an attractive sorbent for removing aromatic organoarsenicals from wastewater. OBJECTIVES The tumor secretome deconvolution is a promising strategy to identify diagnostic and prognostic biomarkers. Here, transcriptomic-based secretome analysis was performed aiming to discover laryngeal squamous cell carcinomas (LSCC) biomarkers from potentially secreted proteins (PSPs). MATERIAL AND METHODS The tumor expression profile (35 LSCC biopsies compared with surrounding normal tissues - SN) revealed 589 overexpressed genes. This gene list was used for secretome analysis based on laryngeal tumors and related secretome databases. RESULTS Forty-nine (Laryngeal tumor secretome database) and 50 (Human Protein Atlas and Cancer Secretome Database) PSPs presented an association with worse overall survival. Specifically, DSG2 overexpression was strongly correlated with poor survival and distant metastasis. DSG2 increased expression was confirmed in the LSCC dataset (LSCC = 111; SN = 12) from TCGA. A significant association between shorter survival and DSG2 overexpression was also detected. In an independent cohort of cases, we analyzed and confirmed high protein levels of DSG2 in plasma from LSCC patients. CONCLUSION A set of PSPs including the circulating DSG2, were associated with shorter overall survival in LSCC. DSG2 overexpression was also correlated with distant metastasis. The high plasmatic protein levels of DSG2 suggest its potential to be tested in liquid biopsies and applied as prognostic biomarker of LSCC. STUDY OBJECTIVE To assess how the addition of a Pediatric and Adolescent Gynecologist (PAG) in an area where one has not previously been available impacts the use of long acting reversible contraceptive (LARC) among girls age 13-24. DESIGN Retrospective Chart Review SETTING Academic practice including 12 general practice OBGYNs (GP) and one PAG, and Title X clinics in three neighboring counties in West Virginia. PARTICIPANTS Patients receiving an intrauterine device (IUD) or implant during 2010-2016. INTERVENTIONS Subject charts were reviewed for age and date at insertion, provider (GP, PAG and Title X), device type, parity, discontinuation and sequential LARC placement. MAIN OUTCOME MEASURES Frequencies of LARC and RR with 95% confidence interval were calculated for the 13-17 and 18-24 year age groups and compared between provider type. RESULTS Frequency of LARC increased over time for all providers for subjects 13-24; the PAG had the highest frequency of LARC among age 13-17. The RR for IUD provision for the PAG provider among 13-17 year olds was 3.1 and 32.5 times greater compared to GP and Title X (p less then 0.001). Title X providers were 2.9 (2.27, 3.79) and 2.8 (2.06, 3.81) times more likely to provide implants to patients age 13-17 compared to PAG and GP, respectfully (p less then 0.001). CONCLUSIONS A PAG provider can have a positive impact on LARC uptake among adolescents in a community where this specialist has not previously been available. ACY-241 research buy This is most noted among 13-17 year old patients receiving IUDs. STUDY OBJECTIVE Data regarding trial of labor after cesarean delivery (TOLAC) among young women are limited. The aim of this study was to assess the TOLAC success rate and its related factors among adolescents who had never delivered vaginally. DESIGN A multicenter retrospective cohort study of all adolescent women aged ≤21 years with a history of one previous cesarean delivery, who delivered in two tertiary medical centers during 2007-2019. Women were allocated to two groups 1) women who underwent TOLAC 2) women who had a repeat cesarean delivery with no trial of labor. Maternal and neonatal outcomes were compared between the two groups. In addition, perinatal outcomes were compared between women with successful and unsuccessful TOLAC. RESULTS The study cohort included 167 women who had a previous caesarean delivery, 117 underwent TOLAC and 50 underwent a repeat cesarean delivery with no trial of labor. Neonatal birth weight (median 2937 vs. 3170, p=0.03) and gestational age at delivery (median 38 weeks vs. ith a relatively high success rate. Adolescents in the United States are too often involved in relationships characterized by coercion and violence. An emerging body of research suggests that dating violence is linked with other health risks in adolescent relationships, particularly sexual risk behavior. The confluence of risks conferred by dating violence and sexual risk behavior are particularly acute for adolescent girls. Adolescent gynecology providers need to understand the nature of dating violence in adolescence and the ways in which dating violence and sexual risk behavior are mutually influential. This article reviews the literature on the links between dating violence and sexual risk in adolescent girls' relationships. The prevalence, risk factors, and consequences of dating violence in adolescence are discussed, followed by a review of the research linking dating violence and sexual risk, with a focus on common mechanisms underlying these relationship risk behaviors. The review concludes with implications for screening, prevention, intervention, and future directions for research. STUDY OBJECTIVE Occurrence and characteristics of contraception discussions with adolescents are unexplored. Our study sought to address this gap using transcripts of audiotaped healthcare visits. DESIGN, SETTING, AND PARTICIPANTS This study was a secondary analysis of 153 transcripts of medical visits with female adolescents with asthma. Medical visits took place among four outpatient clinics in North Carolina. MAIN OUTCOME MEASURE(S) Transcripts were reviewed for occurrence and characteristics of contraception discussions. Demographics were collected from adolescent interviews, caregiver questionnaires, and provider questionnaires. RESULTS Contraception was mentioned in 3% (n=5) of office visits. Conversations about contraception included the topics of contraception efficacy (20%), contraception side effects (60%), contraception adherence (20%) and adolescent sexual health (20%). No conversations included the topics of contraception indication or alternative methods. CONCLUSIONS Conversations about contraception occurred infrequently.