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97 [95% CI 0.79-1.19]). When adjusted for baseline characteristics (age, height, weight, NYHA functional class, renal insufficiency, EuroScore, and tricuspid regurgitation), sex had no impact on mortality.
In this large, real-world cohort, all-cause mortality trended lower in women than men at 4 years post TAVI; however, several baseline factors, but not sex, were predictors of mortality. No difference between sexes was observed for cardiovascular mortality.
In this large, real-world cohort, all-cause mortality trended lower in women than men at 4 years post TAVI; however, several baseline factors, but not sex, were predictors of mortality. No difference between sexes was observed for cardiovascular mortality.
By activating prostacyclin receptors (IP receptors), prostacyclin (PGI
) exerts cardiovascular protective effects such as vasodilation and inhibition of vascular smooth muscle cell (VSMC) proliferation. However, IP receptors are dysfunctional under pathological conditions, and PGI
produces detrimental effects that are opposite to its physiological protective effects via thromboxane-prostanoid (TP) receptors. This attempted to investigate whether or not IP receptor dysfunction facilitates the shift of PGI
action.
The effects of PGI
and its stable analog iloprost on VSMC phenotypic transformation and proliferation were examined in A10 cells silencing IP receptors, in human aortic VSMCs (HAVSMCs) knocked down IP receptor by CRISPR-Cas9, or in HAVSMCs transfected with a dysfunctional mutation of IP receptor IP
.
PGI
/iloprost treatment stimulated cell proliferation, upregulated synthetic proteins and downregulated contractile proteins, suggesting that PGI
/iloprost promotes VSMC phenotypic trareceptors. The VSMC detrimental effect of PGI2 medicated by IP dysfunction and TP activation might probably exacerbate vascular remodelling, accelerating cardiovascular diseases.Dyslipidemia is associated with autonomic nervous system (ANS) dysfunction. Heart rate variability (HRV) is a powerful tool for evaluating the ANS and for cardiovascular risk stratification. Yet, the methodologies used are impractical in most clinical settings and therefore, are usually not applied. The current study aimed to evaluate the reliability of ultra-short HRV parameters, which are easily calculated from any standard ECG, as a practical method for ANS study, with a focus on patients with dyslipidemia. Fifty-nine volunteers with dyslipidemia underwent HRV study of parametric and power spectral indices according to accepted methods. Correlations were calculated between ultra-short HRV indices (five 1-min and five 10-s segments) and standard 5-min recordings. Correlations were found between 10-s and 1-min RMSSD and 5-min recordings (mean Pearson ρ correlation coefficients of 0.913 and 0.944, respectively, and mean concordance correlation coefficients of 0.855 and 0.938, respectively). Angiogenesis inhibitor Associations were found between other ultra-short HRV parameters (SDNN, maximum RR, minimum RR, pNN50, ln(RMSSD) and 5-min recordings. In addition, average RR, HRV-TI, NN50, TP, LF/HF, ln(SDNN), ln(HRV-TI), ln(TP) and ln(LF/HF) from 1-min recordings were associated with 5-min values. In conclusion, some ultra-short HRV parameters can be used for ANS evaluation and presumably, for cardiovascular risk stratification among patients with dyslipidemia. These parameters seem to be of great practical value for both inpatient and outpatient settings, because most can be calculated from a standard 10-s ECG strip. The prognostic implications of ECG-derived, ultra-short HRV parameters in patients with dyslipidemia should be further evaluated in future studies.
To analyze the correlation between the appearance of signs/symptoms during a cardiovascular rehabilitation program and linear indexes of the heart rate variability (HRV) at rest.
To carry out the present observational longitudinal study, 48 patients were analyzed. The protocol was divided into two stages. First, the patients had their personal details collected, and the autonomic modulation at rest was evaluated by HRV. Second, they underwent 36 sessions of the cardiovascular rehabilitation program to evaluate signs/symptoms. Then, just for analysis of the data, they were divided into two groups the group without signs/symptoms (n = 26; 65.15 ± 9.7 years); and the group with signs/symptoms (n = 22; 66.77 ± 14.4 years). The HRV indexes were compared by ancova. The effect size was measured through the partial eta-squared. Pearson's and Spearman's correlations (P < 0.05) were used to analyze the data, and linear regression was applied.
A total of 103 signs/symptoms occurred. The group with signs/symptomFor rMSSD, SD1 and SD1/SD2, the lower the values of these HRV indexes, the greater the risk of appearance of signs/symptoms. Geriatr Gerontol Int 2020; 20 853-859.
Patients with lower HRV are more likely to have signs/symptoms. The rMSSD, pNN50, HF (expressed as ms2 ), SD1 and SD1/SD2 index presented a negative correlation with the appearance of signs/symptoms. For rMSSD, SD1 and SD1/SD2, the lower the values of these HRV indexes, the greater the risk of appearance of signs/symptoms. Geriatr Gerontol Int 2020; 20 853-859.The familial resemblance in length of adult life is very modest. Studies of parent-offspring and twins suggest that exceptional health and survival have a stronger genetic component than lifespan generally. To shed light on the underlying mechanisms, we collected information on Danish long-lived siblings (born 1886-1938) from 659 families, their 5379 offspring (born 1917-1982), and 10,398 grandchildren (born 1950-2010) and matched background population controls through the Danish 1916 Census, the Civil Registration System, the National Patient Register, and the Register of Causes of Death. Comparison with the background, population revealed consistently lower occurrence of almost all disease groups and causes of death in the offspring and the grandchildren. The expected incidence of hospitalization for mental and behavioral disorders was reduced by half in the offspring (hazard ratio 0.53, 95% confidence interval 0.45-0.62) and by one-third in the grandchildren (0.69, 0.61-0.78), while the numbers for tobacco-related cancer were 0.