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This study investigated a novel SPECT agent for the noninvasive imaging of EGFR-overexpressing tumors.

The EGFR-targeting peptide GE11 was synthesized with the introduction of four amino acids (GGGC) to its C-terminal to act as a strong chelator and radiolabeled using

Tc. The radiochemical yield of the

Tc-peptide-GE11 were evaluated using RP-HPLC. Cellular assays of the probe were performed on two NSCLC cell lines A549 (high expression) and H23 (low expression). Biodistribution and SPECT imaging were performed in BALB/c nude mice bearing A549 and H23 NSCLC xenografts.

The

Tc-peptide-GE11 was prepared at high efficiency with radiochemical yield of 98.40 ± 1.00 % and it showed favorable stability. The cellular uptake was significantly higher in A549 than in H23 at all time points (especially at 1 h, which was 10.34 ± 0.72 and 2.04 ± 0.18, respectively). A nearly 56% reduction in probe uptake was observed after pretreatment with excess unlabeled peptides. The performance of SPECT imaging and biodistribution demonstrated higher uptake of the

Tc-peptide-GE11 in A549 xenograft than in H23 xenografts.

The new SPECT tracer

c-peptide-GE11 showed EGFR specificity, favorable pharmacokinetics and great potential for EGFR-targeted imaging.

The new SPECT tracer 99mTc-peptide-GE11 showed EGFR specificity, favorable pharmacokinetics and great potential for EGFR-targeted imaging.

To identify viral pathogens in patients with secondary glaucoma associated with anterior segment uveitis and compare metagenomic deep sequencing (MDS) with enzyme-linked immunosorbent assay (ELISA) combined with Witmer-Desmonts coefficient (WDC) evaluation and real-time quantitative polymerase chain reaction (qPCR) on investigating pathogens in aqueous humor.

Aqueous humor from 31 patients, including 22 Posner-Schlossman Syndrome and 9 other anterior uveitis, was assessed pathogens by ELISA combined with WDC evaluation, virus deoxyribonucleic acid (DNA) detection by real-time qPCR and MDS.

Viral pathogens (HCMV or VZV or RV) were detected in 19 out of 31 eyes (61.3%) by real-time qPCR or WDC evaluation. MDS revealed the presence of HCMV DNA sequences in three PSS patients.

Virus is an important pathogen in secondary glaucoma associated with anterior segment uveitis. MDS is a potential etiologic diagnosis tool to seek intraocular viral pathogens for secondary glaucoma associated anterior segment uveitis.

Virus is an important pathogen in secondary glaucoma associated with anterior segment uveitis. Selleck Ki16198 MDS is a potential etiologic diagnosis tool to seek intraocular viral pathogens for secondary glaucoma associated anterior segment uveitis.Living with attention deficit hyperactivity disorder (ADHD) and mental illness involves an increased risk of lifestyle-related diseases. Although there are several ways to provide support to adult persons with ADHD, there is a lack of non-medical strategies for this purpose. This study explore how adult persons with ADHD with mental illness experienced taking part in a nurse-led lifestyle intervention. Fifteen participants participated in a 52-week lifestyle intervention. The analysis revealed two main categories; Building trusting relationships and Health together. This nurse-led lifestyle intervention could be an alternative or complement to current approaches to promoting health in adults with ADHD.

The prevalence of overweight/obesity in China has increased dramatically in recent years; being overweight/obese can increase the risk of type 2 diabetes and cardiovascular disease. The purpose of this study was to determine the population in China at high risk of being overweight or obese, to explore the relationships between various relevant factors and overweight/obesity, and to identify preventive efforts for high-risk populations.

We administered a questionnaire survey among a group of 536 social workers in Shijiazhuang City in 2017. We used the Pearson chi-square test, Spearman's rho test, multivariate linear regression, univariate and multivariate logistic regression, and receiver operating characteristic curve analysis to investigate factors that influence overweight/obesity.

The prevalence of overweight/obesity was 13.7% among the study participants. Urban residence, eating speed, number of daily meals, overeating, and a high-fat diet were associated with overweight/obesity. In multivariate linear regression analysis, overweight/obesity was correlated with sex, urban residence, eating speed, number of daily meals, and a high-fat diet.

Among all influencing factors, dietary factors, place of residence, and sex were most closely related to being overweight/obese. Furthermore, living in an urban area and male sex were independent risk factors for being overweight/obese.

Among all influencing factors, dietary factors, place of residence, and sex were most closely related to being overweight/obese. Furthermore, living in an urban area and male sex were independent risk factors for being overweight/obese.

To understand the perceptions of falls risk and falls prevention, and the perceived enablers and barriers to engaging in falls prevention strategies/activities among people with doctor-diagnosed hip and/or knee osteoarthritis.

A qualitative study utilising semi-structured telephone interviews. Researchers independently analysed qualitative data using an inductive method guided by the COM-B framework. Interviews were analysed thematically using open, axial, and selective coding. Recruitment ceased at 20 interviews, once data saturation was evident.

Participants were 18 women and two men aged 52-84years and half had fallen in the last 12months. Main themes were the absence of recommendations to access activities after having a fall, inconsistencies between perceptions of the relationship between OA and falls, and individual beliefs of not being at risk of falling because of taking precautions. Knowledge about falls prevention programs was limited, the term "falls prevention" was considered stigmatising anence of keeping active. Re-framing the language used to discuss falls is recommended to promote uptake of falls prevention activities. Implications for rehabilitation Despite growing evidence that osteoarthritis (OA) is an independent risk factor for falls, people with OA do not perceive themselves to be at risk and falls prevention is for those who are "old and frail". Re-framing the language used to discuss falls and falls prevention to focus on positive messages may promote the uptake of falls prevention activities in this population. Improving the awareness of falls and falls risk among people with OA through effective health education is needed in order to foster the uptake of, and engagement with, falls prevention activities.