Ladegaardreece7575

Many animal species cooperate with conspecifics in various social contexts. While ultimate causes of cooperation are being studied extensively, its proximate causes, particularly endocrine mechanisms, have received comparatively little attention. Here, we present a study investigating the link between the hormone cortisol, cooperation and social bonds in long-tailed macaques (Macaca fascicularis). We tested 14 macaques in a dyadic cooperation task (loose-string paradigm), each with two partners of different social bond strength and measured their salivary cortisol before and after the task. We found no strong link between the macaques' cortisol level before the task and subsequent cooperative success. By contrast, we did find that the act of cooperating in itself led to a subsequent decrease in cortisol levels, but only when cooperating with closely bonded individuals. Two control conditions showed that this effect was not due to the mere presence of such an individual or the pulling task itself. Consequently, our study shows an intricate way in which the hypothalamic-pituitary-adrenal axis is involved in cooperation. Future studies should reveal whether and how our findings are driven by the anxiolytic effect of oxytocin, which has been associated with social bonding.Whether moral cognition is underpinned by distinct mental systems that process different domains of moral information (moral pluralism) is an important question for moral cognition research. The reduced importance of intent (intentional versus accidental action) when judging purity (e.g. incest), when compared with harm (e.g. poisoning), moral violations is, arguably, some of the strongest experimental evidence for distinct moral systems or 'foundations'. The experiment presented here is a replication attempt of these experimental findings. A pre-registered replication of Experiment 1B from the original article documenting this effect was conducted in a sample of N = 400 participants. Findings from this successful replication are discussed in terms of theoretical and methodological implications for approaches to moral cognition.Foraging is a behaviour that can be influenced by multiple factors and is highly plastic. Recent studies have shown consistency in individual foraging behaviour has serious ecological and evolutionary implications within species and populations. Such information is crucial to understand how species select habitats, and how such selection might allow them to adapt to the environmental changes they face. Five foraging metrics (maximum distance from the colony, bearing from the colony to the most distal point, tortuosity index, total number of dives and mean vectorial dynamic body acceleration were obtained using GPS tracking and accelerometry data in adult Australasian gannets (Morus serrator) from two colonies in southeastern Australia. Individuals were instrumented over two breeding seasons to obtain data to assess factors influencing foraging behaviour and behavioural consistency over multiple timescales (consecutive trips, breeding stages and years) and habitats (pelagic, mixed pelagic and inshore, and inshore). Colony, breeding stage and year were the factors which had the greatest influence on foraging behaviour, followed by sex. Behavioural consistency, measured as the contribution of the individual to the observed variance, was low to moderate for all foraging metrics (0.0-27.05%), with the higher values occurring over shorter timescales. In addition, behavioural consistency was driven by spatio-temporal factors rather than intrinsic characteristics. Behavioural consistency was higher in individuals foraging in inshore than pelagic habitats or mixed pelagic/inshore strategy, supporting suggestions that consistency is favoured in stable environments.Background In recent years an increasing number of patients with cerebral metastasis (CM) have been referred to the neuro-oncology multidisciplinary team (NMDT). Our aim was to obtain a national picture of CM referrals to assess referral volume and quality and factors affecting NMDT decision making. Leurocristine Methods A prospective multicenter cohort study including all adult patients referred to NMDT with 1 or more CM was conducted. Data were collected in neurosurgical units from November 2017 to February 2018. Demographics, primary disease, KPS, imaging, and treatment recommendation were entered into an online database. Results A total of 1048 patients were analyzed from 24 neurosurgical units. Median age was 65 years (range, 21-93 years) with a median number of 3 referrals (range, 1-17 referrals) per NMDT. The most common primary malignancies were lung (36.5%, n = 383), breast (18.4%, n = 193), and melanoma (12.0%, n = 126). A total of 51.6% (n = 541) of the referrals were for a solitary metastasis and resulted in specialist intervention being offered in 67.5% (n = 365) of cases. A total of 38.2% (n = 186) of patients being referred with multiple CMs were offered specialist treatment. NMDT decision making was associated with number of CMs, age, KPS, primary disease status, and extent of extracranial disease (univariate logistic regression, P less then .001) as well as sentinel location and tumor histology (P less then .05). A delay in reaching an NMDT decision was identified in 18.6% (n = 195) of cases. Conclusions This study demonstrates a changing landscape of metastasis management in the United Kingdom and Ireland, including a trend away from adjuvant whole-brain radiotherapy and specialist intervention being offered to a significant proportion of patients with multiple CMs. Poor quality or incomplete referrals cause delay in NMDT decision making.Background Diffuse low-grade gliomas (DLGGs) are heterogeneous tumors that inevitably differentiate into malignant entities, leading to disability and death. Recently, a shift toward up-front maximal safe resection of DLGGs has been favored. However, this transition is not supported by randomized controlled trial (RCT) data. Here, we sought to survey the neuro-oncology community on considerations for a surgical RCT for DLGGs. Methods A 21-question survey focusing on a surgical RCT for DLGGs was developed and validated by 2 neurosurgeons. A sample case of a patient for whom management might be debatable was presented to gather additional insight. The survey was disseminated to members of the Society for Neuro-Oncology (SNO) and responses were collected from March 16 to July 10, 2018. Results A total of 131 responses were collected. Sixty-three of 117 (54%) respondents thought an RCT would not be ethical, 39 of 117 (33%) would consider participating, and 56 of 117 (48%) believed an RCT would be valuable for determining the differing roles of biopsy, surgery, and observation.