Gustavsenrask2357

In this work, N and MoS2 quantum dot co-doped uniform 2D carbon nanoflakes are synthesized. Owing to its high quantum dot content of 54.56 wt%, the sample exhibits excellent rapid charging performance when used as an anode material in Li-ion batteries, even under a current density of 10 A g-1.The present study aimed to investigate the relationship between the n-3 index, serum metabolites and breast cancer risk. A total of 104 newly diagnosed breast cancer patients and 70 healthy controls were recruited. The erythrocyte phospholipid fatty acid composition was determined by gas-liquid chromatography, and the n-3 index was calculated with the percentage of eicosapentaenoic acid plus docosahexaenoic acid in total fatty acids. Serum metabolomic profiles were analyzed by UHPLC-Q-Exactive Orbitrap/MS. The results showed that the erythrocyte phospholipid n-3 index was significantly lower in breast cancer patients than in healthy controls, and it was inversely associated with breast cancer risk (OR = 0.60; 95% CI 0.36-0.84). Metabolomics analyses showed that serum 16α-hydroxy dehydroepiandrosterone (DHEA) 3-sulfate, lysophatidylethanolamines (LPE) 220/00 and hexanoylcarnitine were significantly higher, while thromboxane B3, prostaglandin E3 (PGE3) and 18β-glycyrrhetinic acid were significantly lower in breast cancer patients than those in healthy controls. In addition, serum 16α-hydroxy DHEA 3-sulfate was inversely correlated with the n-3 index (r = -0.412, p = 0.036). In conclusion, our findings suggest that the lack of n-3 PUFAs might be a potential risk factor for breast cancer, and the serum metabolite 16α-hydroxy DHEA 3-sulfate may play an important role in linking n-3 PUFA deficiency and breast disease etiology.Correction for 'Vinylboronic acid pinacol ester as a vinyl alcohol-precursor monomer in radical copolymerization with styrene' by Hiroshi Makino et al., Chem. Commun., 2021, DOI 10.1039/D1CC02603H.In this work we report a joint experimental and computational study on the 2,5-dimethylfuran oxidation reaction in the gas phase initiated by atomic oxygen O(3P). The experiments have been performed by using vacuum-ultraviolet synchrotron radiation at the Advanced Light Source (ALS) of the Lawrence Berkeley National Laboratory (LBNL), at a temperature of 550 K and a pressure of 8 Torr. The experimental data were supported by quantum-chemical calculations along with a kinetic model, also taking into account the possible involvement of different magnetic states, performed in the framework of the RRKM theory. Propyne, acetaldehyde, methylglyoxal, dimethylglyoxal, 3-penten-2-one, 2,5-dimethylfuran-3(2H)-one, and 1,2-diacetyl ethylene have been identified as the main primary products arising under the conditions of the experiment. Durvalumab in vitro Our computational model suggests that these species can be formed at the concentration and branching ratio experimentally observed only in the presence of a non-negligible fraction of non-thermalized intermediates.Gold nanoclusters (AuNCs)-based nanozymes have been studied widely as they provide unrivaled advantages in terms of preferable enzyme-like activities, high stability, and good biocompatibility. Although the enzyme-like catalytic activity of AuNCs has been the object of extensive investigation, understanding how charges or reactive oxygen species on the surfaces of AuNCs can enhance their catalytic performance in the colorimetric sensing of drugs by regulating the catalytic activity of AuNCs is still a big challenge. Herein, l-tryptophanonitrile (LTN)-protected AuNCs (LTN@AuNCs) were prepared, and their nanozyme activity was investigated in the catalytic oxidation process of the peroxidase substrate, namely 3,3',5,5'-tetramethylbenzidine, in the prescence of hydrogen peroxide. Oxytetracycline induced the aggregation of LTN@AuNCs due to the electrostatic interaction between the positively charged LTN@AuNCs and the negatively charged drug. Importantly, the aggregated LTN@AuNCs produced more reactive oxygen species and significantly boosted their peroxidase-like activity. Subsequently, a colorimetric method for highly specific and sensitive detection of oxytetracycline was establised. The ultraviolet-visible absorbance at a wavelength of 650 nm of the aggregated-LTN@AuNCs exhibited a good linear relationship with oxytetracycline in a range of 0.5-15.0 μM (R2 = 0.994). The limit of detection was 0.3 μM. After oxytetracycline was abdominally injected in rats, the metabolic process of the drug in serums was further investigated by using the proposed sensing protocol. The improvable catalytic activity capability of the AuNCs-based nanozymes discloses its great potential in real bio-applications.Modular construction of polyfunctional arenes from abundant feedstocks stands as an unremitting pursue in synthetic chemistry, accelerating the discovery of drugs and materials. Herein, using the multiple C-H activation strategy with versatile imidate esters, the expedient delivery of molecular libraries of densely functionalized sulfur-containing arenes was achieved, which enabled the concise construction of biologically active molecules, such as Bipenamol.

The federal Cannabis Act came into force on Oct. 17, 2018, in Canada, making Canada only the second country in the world to legalize the cultivation, acquisition, possession and consumption of cannabis and its by-products. This provided a unique opportunity to evaluate the impact of this legislation on drug-related trauma.

We performed a prospective observational study on the use of cannabis and other illicit drugs in the trauma population at a lead Canadian trauma centre in London, Ontario, in the 3 months before (July 1 to Sept. 30, 2018) and 3 months after (Nov. 1, 2018, to Jan. 31, 2019) the legalization of cannabis in Canada. We defined cannabis use as a positive cannabinoid screen result at the time of assessment by the trauma team. We also screened for opioids, amphetamines and cocaine.

A total of 210 patients were assessed by our trauma service between July 1 and Sept. 30, 2018, and 141 patients were assessed between Nov. 1, 2018, and Jan. 31, 2019. Motor vehicle collisions were the most common cause of trauma both before (101 [48.