Knighttyson2253

By employing the combination of the perovskite layer and ZnO nanotube, the turn-on voltage of simulated devices has been deceased from 13.7 V to 1.1 V. Moreover, a drastic increment in UV emission from devices based on ZnO nanotube can be seen, which stems from occurring the whispering gallery mode and low defects of nanotubes compared to nanorod. A red-shift causing by the reduction of the bandgap of nanostructures can be observed in EL spectra, too.Objective.To develop an automated system to classify the severity of hypoxic-ischaemic encephalopathy injury (HIE) in neonates from the background electroencephalogram (EEG).Approach. By combining a quadratic time-frequency distribution (TFD) with a convolutional neural network, we develop a system that classifies 4 EEG grades of HIE. The network learns directly from the two-dimensional TFD through 3 independent layers with convolution in the time, frequency, and time-frequency directions. Computationally efficient algorithms make it feasible to transform each 5 min epoch to the time-frequency domain by controlling for oversampling to reduce both computation and computer memory. The system is developed on EEG recordings from 54 neonates. Then the system is validated on a large unseen dataset of 338 h of EEG recordings from 91 neonates obtained across multiple international centres.Main results.The proposed EEG HIE-grading system achieves a leave-one-subject-out testing accuracy of 88.9% and kappa of 0.84 on the development dataset. Accuracy for the large unseen test dataset is 69.5% (95% confidence interval, CI 65.3%-73.6%) and kappa of 0.54, which is a significant (P less then 0.001) improvement over a state-of-the-art feature-based method with an accuracy of 56.8% (95% CI 51.4%-61.7%) and kappa of 0.39. Performance of the proposed system was unaffected when the number of channels in testing was reduced from 8 to 2-accuracy for the large validation dataset remained at 69.5% (95% CI 65.5%-74.0%).Significance.The proposed system outperforms the state-of-the-art machine learning algorithms for EEG grade classification on a large multi-centre unseen dataset, indicating the potential to assist clinical decision making for neonates with HIE.Organometallic sandwich clusters and nanowires can offer prototypes for molecular ferromagnet and nanoscale spintronic devices due to the strong coupling of local magnetic moments in the nanowires direction and experimental feasibility. Tyrphostin B42 purchase Here, on the basis of first-principles calculations, we reportTMn(c-C3H2)n+1(TM= Ti, Mn;n= 1-4) sandwich clusters and 1D [TM(c-C3H2)]∞sandwich nanowires building from transitional metal and the smallest aromatic carbene of cyclopropenylidene (c-C3H2). Based on the results of lattice dynamic and thermodynamic studies, we show that the magnetic moment of Mnn(c-C3H2)n+1clusters increases linearly with the number ofn, and 1D [Mn(c-C3H2)]∞nanowire is a stable ferromagnetic semiconductor, which can be converted into half metal with carrier doping. In contrary, both Tin(c-C3H2)n+1and 1D [Ti(c-C3H2)]∞nanowire are nonmagnetic materials. This study reveals the potential application of the [TM(c-C3H2)]∞nanowire in spintronics.In this work we adapt rare-earth-ion-doped NaYF4nanoparticles coated with a silicon oxide shell (NaYF420%Yb,0.2%Tm@SiO2) for biological and medical applications (for example, imaging of cancer cells and therapy at the nano level). The wide upconversion emission range under 980 nm excitation allows one to use the nanoparticles for cancer cell (4T1) photodynamic therapy (PDT) without a photosensitizer. The reactive oxygen species (ROS) are generated by Tm/Yb ion upconversion emission (blue and UV light). Thein vitroPDT was tested on 4T1 cells incubated with NaYF420%Yb,0.2%Tm@SiO2nanoparticles and irradiated with NIR light. After 24 h, cell viability decreased to below 10%, demonstrating very good treatment efficiency. High modification susceptibility of the SiO2shell allows for attachment of biological molecules (specific antibodies). In this work we attached the anti-human IgG antibody to silane-PEG-NHS-modified NaYF420%Yb,0.2%Tm@SiO2nanoparticles and a specifically marked membrane model by bio-conjugation. Thus, it was possible to perform a selective search (a high-quality optical method with a very low-level organic background) and eventually damage the targeted cancer cells. The study focuses on therapeutic properties of NaYF420%Yb,0.2%Tm@SiO2nanoparticles and demonstrates, upon biological functionalization, their potential for targeted therapy.Nodal line semimetals (NLSM) exhibit interesting quantum oscillation (QO) characteristics when acted upon by a strong magnetic field. We study the combined effect of strong direct and alternating magnetic field, perpendicular to the nodal plane in an untilted NLSM in order to probe the behavior of the low lying Landau level states that can periodically become gapless for suitably chosen field parameters. The oscillatory field variation, as opposed to a steady one, has interesting impact on the QO phenomena with the Landau tubes crossing the Fermi surface extremally two times per cycle. Furthermore, the low energy modes can witness Landau-Zener like transitions between valence and conduction band providing further routes to conduction. We discuss such transition phenomena following the framework of adiabatic-impulse approximation for slow quenches. Next we also investigate the effect of oscillating magnetic field acting parallel to the nodal loop where topologically nontrivial magnetic oscillations at low energies can be witnessed. Therefore, with proper parameters chosen, one can engineer topological transitions to occur periodically in such systems as the oscillating field is swept through its cycles.Mandibular hypoplasia, Deafness and Progeroid features with concomitant Lipodystrophy define a rare systemic disorder, named MDPL Syndrome, due to almost always a de novo variant in POLD1 gene, encoding the DNA polymerase δ. We report a MDPL female heterozygote for the recurrent p.Ser605del variant. In order to deepen the functional role of the in frame deletion affecting the polymerase catalytic site of the protein, cellular phenotype has been characterised. MDPL fibroblasts exhibit in vitro nuclear envelope anomalies, accumulation of prelamin A and presence of micronuclei. A decline of cell growth, cellular senescence and a blockage of proliferation in G0/G1 phase complete the aged cellular picture. The evaluation of the genomic instability reveals a delayed recovery from DNA induced-damage. Moreover, the rate of telomere shortening was greater in pathological cells, suggesting the telomere dysfunction as an emerging key feature in MDPL. Our results suggest an alteration in DNA replication/repair function of POLD1 as a primary pathogenetic cause of MDPL.