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In one patient (2.7%), Lewy body dementia was diagnosed at 46 years of age. Bone lesion onset was late and usually a single event in most patients. This analysis highlights the genotypic heterogeneity of this subgroup, in which disease could remain stable and even improve spontaneously. It also draws attention to the possible risk of Lewy body disease and late onset of bone complications, even if isolated, to be confirmed in larger series and with longer follow-up.The original pattern recognition and classification of crop diseases needs to collect a large amount of data in the field and send them next to a computer server through the network for recognition and classification. This method usually takes a long time, is expensive, and is difficult to carry out for timely monitoring of crop diseases, causing delays to diagnosis and treatment. With the emergence of edge computing, one can attempt to deploy the pattern recognition algorithm to the farmland environment and monitor the growth of crops promptly. However, due to the limited resources of the edge device, the original deep recognition model is challenging to apply. Due to this, in this article, a recognition model based on a depthwise separable convolutional neural network (DSCNN) is proposed, which operation particularities include a significant reduction in the number of parameters and the amount of computation, making the proposed design well suited for the edge. To show its effectiveness, simulation results are compared with the main convolution neural network (CNN) models LeNet and Visual Geometry Group Network (VGGNet) and show that, based on high recognition accuracy, the recognition time of the proposed model is reduced by 80.9% and 94.4%, respectively. Given its fast recognition speed and high recognition accuracy, the model is suitable for the real-time monitoring and recognition of crop diseases by provisioning remote embedded equipment and deploying the proposed model using edge computing.Melatonin, a pivotal photoperiodic signal transducer, may work as a brown-fat inducer that regulates energy balance. Our study aimed to investigate the effects of melatonin treatment on the body fat accumulation, lipid profiles, and circulating irisin of rats with high-fat diet-induced obesity (DIO). Methods 30 male Sprague-Dawley rats were divided into five groups and treated for 8 weeks vehicle control (VC), positive control (PC), MEL10 (10 mg melatonin/kg body weight (BW)), MEL20 (20 mg/kg BW), and MEL50 (50 mg/kg BW). The vehicle control group was fed a control diet, and the other groups were fed a high-fat and high-calorie diet for 8 weeks to induce obesity before the melatonin treatment began. MSC2530818 solubility dmso Melatonin reduced weight gain without affecting the food intake, reduced the serum total cholesterol level, enhanced the fecal cholesterol excretion, and increased the circulating irisin level. Melatonin downregulated the fibronectin type III domain containing 5 (FNDC5) and lipoprotein lipase (LPL) mRNA expressions of inguinal white adipose tissue (iWAT) and induced the browning of iWAT in both the MEL10 and MEL20 groups. Conclusion Chronic continuous melatonin administration in drinking water reduced weight gain and the serum total cholesterol levels. Additionally, it enhanced the circulating irisin, which promoted brite/beige adipocyte recruitment together with cholesterol excretion and contributed to an anti-obesity effect.Whole grains may assist in reducing risk of non-communicable disease, but consumption is limited in many countries. In Australia, the reasons for poor consumption are not well understood. The aim of this study was to investigate consumers' knowledge, attitudes and identification of whole grains, incorporating an exploration of factors influencing consumption, promotion and provision. An online semi-structured questionnaire was used to gather responses from 735 participants (61% complete responses). Although 92% of respondents consumed grains, only 8% reported an intake consistent with age and gender recommendations. Refined pasta and rice were the most frequently purchased grain foods followed by wholemeal/whole grain bread. Of whole grain foods, bread and breakfast cereals were consumed more frequently. However, overall, participants did not prioritise consumption of whole grains. Despite this, 93% of participants had seen food packaging information drawing attention to whole grain content, with a high proportion describing whole grain as less processed (72%) or high in dietary fibre (67%). Two-thirds were aware of health benefits but stated that if they had further information, they would be more likely to swap to whole grain. Further education, increasing exposure, accessibility and extensive promotion of whole grain health benefits are required to facilitate whole grain consumption. Furthermore, removing the negative stigma associated with carbohydrate foods, including grains, will be necessary to improve consumption.The effects of build orientation and heat treatment on the crack growth behavior of 316L stainless steel (SS) fabricated via a selective laser melting additive manufacturing process were investigated. Available research results on additively manufactured metallic parts still require a substantial expansion. The most important issue connected with the metal properties after additive manufacturing are the high anisotropy properties, especially from the fatigue point of view. The study examined the crack growth behavior of additively manufactured 316L in comparison to a conventionally made reference material. Both groups of samples were obtained using precipitation heat treatment. Different build orientations in the additively manufactured samples and rolling direction in the reference samples were taken into account as well. Precipitation heat treatment of additively manufactured parts allowed one to achieve microstructure and tensile properties to similar to those of conventionally made pieces. The heat treatment positively affected the fatigue properties. Additionally, precipitation heat treatment of additively manufactured elements significantly affected the reduction of fatigue cracking velocity and changed the fatigue cracking mechanism.