Brewerbaxter2625
Modern statistical methods, such as the design of experiments and response surface methodology, are widely used to describe changes in multiparameter processes during the processing of food in both science and technology contexts. However, these approaches are described to a lesser degree in the case of cocoa roasting than other foods and processes. Our study aimed to use the design of experiments to establish a model of cocoa roasting for relevant flavor-related constituents. We have used HPLC-MS techniques to link standard process parameters with chemical compounds changing in concentration during cocoa roasting. Influence of time, temperature, the addition of water, acid, and base, on relative concentrations of procyanidin monomers, dimers, and trimers, an Amadori compound, and a peptide, was shown. High-quality models for each compound were established and validated, displaying good prediction accuracy. Such an approach could be used to optimize processing conditions for cocoa roasting in order to influence the concentration of certain chemical compounds, and in turn, improving the flavor of chocolate products.
Although the symptoms attributed to gall stones resolve in most patients after cholecystectomy, some may have symptoms that persist or recur. It is known as the post-cholecystectomy syndrome (PCS). The aim of this case was to describe the diagnostic difficulties encountered and to discuss the main etiologies of this entity.
A 54-year-old man presented for a recurrent right upper quadrant pain despite laparoscopic cholecystectomy five years ago. Imaging showed cystic lesion at the gallbladder fossa with gallstones. We decided to reoperate the patient by laparoscopic approach. It turned to be a residual gallbladder with stones inside. It was confirmed by histopathology. He was asymptomatic after a follow-up of 2years.
The PCS should not be trivialized. Most of the causes are allocated to extra biliary etiologies. They must be ruled out first as most of them can be controlled with medication. There are etiologies for which re-operation can be necessary.
The indication of cholecystectomy must be taken wisely otherwise surgery will not solve the problem. Even though patient may complain of persistence or recurrence of the pain. In this case, it can be a real challenge for both diagnosis and treatment.
The indication of cholecystectomy must be taken wisely otherwise surgery will not solve the problem. Even though patient may complain of persistence or recurrence of the pain. In this case, it can be a real challenge for both diagnosis and treatment.
Recently cementless total hip arthroplasty (THA) has shown good long-term results with excellent stability resulted from the porous coating of the implant. A hydroxyapatite-tricalcium phosphate (HA-TCP) coating on the porous surface is expected to promote bone ingrowth and to improve initial fixation of the implant. Here we report a case of bone ingrowth observed in a cup removed during revision surgery for early dislocation, 37days after primary THA using a porous coating cup with HA-TCP.
A 61-year-old woman who has bilateral osteoarthritis underwent same-day bilateral THA. Both sides used porous coating cups with HA-TCP. Line-to-line technique and screw fixation were utilized. Anterior dislocation of the left hip occurred on days 27 and 31, and we performed cup revision on day 37 after surgery. read more We noted bone-like tissue on the posterior surface of the cup and in a vacant screw hole. Bone tissue was also confirmed in pathological findings.
Studies in animals have confirmed early bone ingrowth about 4weeks after surgery with HA-TCP coated implants. In humans, the earliest report of bone ingrowth in cups is for a cup without HA-TCP coating, detected 5weeks after surgery. In the present case, we used a porous coating cup with HA-TCP, and bone ingrowth was confirmed at approximately the same time as for the previous case.
Early clinical bone ingrowth was confirmed in an HA-TCP coated cup, occurring at about the same time after surgery as in previous reports.
Early clinical bone ingrowth was confirmed in an HA-TCP coated cup, occurring at about the same time after surgery as in previous reports.This paper designs a systemic framework to quantify speed reduction induced by traffic incidents using a causal inference framework. The results can provide a reference to traffic managers for evaluating incident severities, thus take proper control measures after the incident in order not to underestimate or overestimate the negative impact. A two-phase scheme is proposed, including impacted region determination and speed reduction quantification. We first propose a Frame Region (FR) method, based on the shockwave propagation, to determine the spatiotemporal impacted region (SIR) using speed map. It is worth-noting that we design a statistical experiment to prove the rationality of congestion threshold selection. Secondly, we introduce a causal inference method for identifying the matched freeway segments. The traffic condition of finally matched freeway segments can be served as non-incident traffic condition of the incident occurred location, which contributes to quantifying the incident impact on speed reduction. We further demonstrate the proposed method in a case study by taking advantage of an incident record and related real freeway speed data in China. An interesting observation is that, along with the freeway segments away from the incident location, the congestion duration time of different freeway segments firstly rises and then decreases. The case study also illustrates the impact of incident on speed lasts almost 3 h and the congestion caused by the incident spreads 11 km, while the average causal effect of incident on all the impacted freeway segments is 42.3 km/h.One reality of transportation systems is that vehicular accidents can happen practically anywhere and at any time. An increasing body of research suggests though that spatial and/or temporal dependencies (i.e., clusters or hot spots) among accidents likely exist. Along with understanding where and when such spatiotemporal dependencies may occur, another important facet to consider is the geographic extent or area associated with the hot spots. For example, an accident hot spot may involve a small, isolated portion of the transportation system or a much more expansive geographic area. Better delineation and quantification of the morphological characteristics of accident hotspots can provide valuable decision support for planning for accident hot spot mitigation and prevention. As the size and shape of accident hot spots may evolve over time, the capability to track such dynamics is vital, especially with respect to the identification of processes effecting hot spot occurrence as well as assessments of the efficacy of efforts to mitigate factors underlying hot spot development.