Dallpoole0887

This study aimed to develop sorafenib loaded magnetic microspheres for the treatment of hepatocellular carcinoma. To achieve this goal, superparamagnetic iron oxide nanoparticles (SPIONs) were synthesised and encapsulated in alginate microspheres together with an antineoplastic agent, sorafenib. In the study, firstly SPIONs were synthesised and characterised by dynamic light scattering, energy-dispersive X-ray spectroscopy, and scanning electron microscopy. Then, alginate-SPIONs microspheres were developed, and further characterised by electron spin resonance spectrometer and vibrating sample magnetometer. Besides the magnetic properties of SPIONs, alginate microspheres with SPIONs were also found to have magnetic properties. The potential use of microspheres in hyperthermia treatment was then investigated and an increase of about 4°C in the environment was found out. Drug release studies and cytotoxicity tests were performed after sorafenib was encapsulated into the magnetic microspheres. According to release studies, sorafenib has been released from microspheres for 8 h. Cytotoxicity tests showed that alginate-SPION-sorafenib microspheres were highly effective against cancerous cells and promising for cancer therapy.Logic expressions can be designed from actin filaments. It is a protein that makes the cellular structure and plays an important role in intracellular communication. Nano communication technique has been established using actin cellular automata. Among several rules, (1, 30) and (4, 27) rules have been used to design 2 to 1 multiplexer, 4 to 1 multiplexer, 1 to 2 demultiplexer and 1 to 4 demultiplexer. Router or data selector has been made of using multiplexer and demultiplexer. Three novel circuits such as multiplexer, demultiplexer and nano-router have been designed using the projected mechanism. The primary focus of this proposed technique is on different designs of the multiplexer, demultiplexer and minimum cell count with minimum time steps. The different router circuits have been simulated with the help of Simulink by which output has been verified for different circuits. Stuck at fault analysis is also done in this study. Device density and power consumption have also been included in this study. A comparative analysis of the different designs of the router provides a better concept of circuit optimisation. Furthermore, this study analyses convenient forthcoming applications in nano-technology and nano-bio-molecular systems involving the proposed parameters.Nano-devices are featured to communicate via molecular interaction, the so-called molecular communication (MC). In MC systems, the information is carried by molecules where the amount of molecules constitutes the level of the signal. In this study, an MC-based system was analysed with different receiver topology and related parameters, such as size, shape, and orientation of receptors on the receiver. Also in the concept of nano-medicine, the effect of amyloid-beta ([inline-formula removed]), which is believed as the main cause of Alzheimer disease, on the successful reception ratio of molecules with the proposed receiver models was investigated. It was demonstrated that the cubic receiver model is superior to sphere one in terms of the correct reception ratio of the molecular signal. A cubic model where its edge (not rotated around the centre) is placed across the transmitter demonstrated a better performance in reducing the effect of [inline-formula removed] as compared to the sphere model while a cubic model where its corner (rotated around the centre) is placed across the transmitter demonstrated a worse performance than the spherical model. From this expression, it may be concluded that with the adjustment of topological system parameters the probability of successful reception ratio in MC may be possible.Metal-organic frameworks (MOFs) as drug carriers have many advantages than traditional drug carriers and have received extensive attention from researchers. However, how to regulate the microstructure of MOFs to improve the efficiency of drug delivery and sustained release behaviour is still a big problem for the clinical application. Herein, the authors synthesise surfactant-modified ZIF-8 nanoparticles with different microstructures by using different types of surfactants to modify ZIF-8. The surfactant-modified ZIF-8 nanoparticles have the larger specific surface area and total micropore volumes than the original ZIF-8, which enables doxorubicin (DOX) to be more effectively loaded on the drug carriers and achieve controlled drug sustained release. Excellent degradation performance of ZIF-8 nanoparticles facilitates the metabolism of drug carriers. The formulation was evaluated for cytotoxicity, cellular uptake and intracellular location in the A549 human non-small-cell lung cancer cell line. ZIF-8/DOX nano drugs exhibit higher cytotoxicity towards cells in comparison with free DOX, suggesting the potential application in nano drugs to cancer chemotherapy.Cellulosic coagulant with low crystallinity and surface charge of -19.2 mV were extracted from wet banana peels (WBE) using kitchen-blending method. Functionalization with ferric chloride and aluminium chloride yielded higher surface charge of -23.8 mV (mWBE). Both WBE and mWBE coagulants were used to target cadmium ions from aqueous solution. Coagulants and the floccules (WBEA and mWBEA) were characterized by XRD, FT-IR, zeta sizer nano series, and SEM/EDs. The amount of cadmium ion coagulated was determined using ICP-OES. The FTIR analysis revealed the functional groups involved in the coordination and subsequent removal of the metals ions around 1634 cm-1, ascribed to the C = O vibrational band of carbonyl group. Microscopic analysis revealed that the mWBE is porous and exhibited microfibers with rod-like morphology. HSP990 The effects of parameters such as the initial concentration, coagulant dosage and solution pH were investigated. Coagulation results showed that 10 mg of WBE and mWBE could remove about 80% and 90% of the Cd2+ ions respectively. However; the difference in the performance of both materials does not justify the essence of surface modification. Therefore, WBE is considered more efficient and environmentally friendly. Notwithstanding, the performance of these coagulants in real environmental samples will confirm their robustness.