Pittmanwalton7797

Light scattering by tissue severely limits how deep beneath the surface one can image, and the spatial resolution one can obtain from these images. Diffuse optical tomography (DOT) is one of the most powerful techniques for imaging deep within tissue - well beyond the conventional ∼ 10-15 mean scattering lengths tolerated by ballistic imaging techniques such as confocal and two-photon microscopy. Unfortunately, existing DOT systems are limited, achieving only centimeter-scale resolution. Furthermore, they suffer from slow acquisition times and slow reconstruction speeds making real-time imaging infeasible. We show that time-of-flight diffuse optical tomography (ToF-DOT) and its confocal variant (CToF-DOT), by exploiting the photon travel time information, allow us to achieve millimeter spatial resolution in the highly scattered diffusion regime ( mean free paths). selleck inhibitor In addition, we demonstrate two additional innovations focusing on confocal measurements, and multiplexing the illumination sources allow us to significantly reduce the measurement acquisition time. Finally, we rely on a novel convolutional approximation that allows us to develop a fast reconstruction algorithm, achieving a 100× speedup in reconstruction time compared to traditional DOT reconstruction techniques. Together, we believe that these technical advances serve as the first step towards real-time, millimeter resolution, deep tissue imaging using DOT.Kernel-based methods for support vector machines (SVM) have shown highly advantageous performance in various applications. However, they may incur prohibitive computational costs for large-scale sample datasets. Therefore, data reduction (reducing the number of support vectors) appears to be necessary, which gives rise to the topic of the sparse SVM. Motivated by this problem, the sparsity constrained kernel SVM optimization has been considered in this paper in order to control the number of support vectors. Based on the established optimality conditions associated with the stationary equations, a Newton-type method is developed to handle the sparsity constrained optimization. This method is found to enjoy the one-step convergence property if the starting point is chosen to be close to a local region of a stationary point, thereby leading to a super-high computational speed. Numerical comparisons with several powerful solvers demonstrate that the proposed method performs exceptionally well, particularly for large-scale datasets in terms of a much lower number of support vectors and shorter computational time.We introduce a novel video-rate hyperspectral imager with high spatial, temporal and spectral resolutions. Our key hypothesis is that spectral profiles of pixels within each super-pixel tend to be similar. Hence, a scene-adaptive spatial sampling of a hyperspectral scene, guided by its super-pixel segmented image, is capable of obtaining high-quality reconstructions. To achieve this, we acquire an RGB image of the scene, compute its super-pixels, from which we generate a spatial mask of locations where we measure high-resolution spectrum. The hyperspectral image is subsequently estimated by fusing the RGB image and the spectral measurements using a learnable guided filtering approach. Due to low computational complexity of the superpixel estimation step, our setup can capture hyperspectral images of the scenes with little overhead over traditional snapshot hyperspectral cameras, but with significantly higher spatial and spectral resolutions. We validate the proposed technique with extensive simulations as well as a lab prototype that measures hyperspectral video at a spatial resolution of 600 ×900 pixels, at a spectral resolution of 10 nm over visible wavebands, and achieving a frame rate at 18fps.Attentive listening in a multispeaker environment such as a cocktail party requires suppression of the interfering speakers and the noise around. People with normal hearing perform remarkably well in such situations. Analysis of the cortical signals using electroencephalography (EEG) has revealed that the EEG signals track the envelope of the attended speech stronger than that of the interfering speech. This has enabled the development of algorithms that can decode the selective attention of a listener in controlled experimental settings. However, often these algorithms require longer trial duration and computationally expensive calibration to obtain a reliable inference of attention. In this paper, we present a novel framework to decode the attention of a listener within trial durations of the order of two seconds. It comprises of three modules 1) Dynamic estimation of the temporal response functions (TRF) in every trial using a sequential linear minimum mean squared error (LMMSE) estimator, 2) Extract the N1-P2 peak of the estimated TRF that serves as a marker related to the attentional state and 3) Obtain a probabilistic measure of the attentional state using a support vector machine followed by a logistic regression. The efficacy of the proposed decoding framework was evaluated using EEG data collected from 27 subjects. The total number of electrodes required to infer the attention was four One for the signal estimation, one for the noise estimation and the other two being the reference and the ground electrodes. Our results make further progress towards the realization of neuro-steered hearing aids.In humans, intradermal administration of β-alanine (ALA) and bovine adrenal medulla peptide 8-22 (BAM8-22) evokes the sensation of itch. Currently, it is unknown which human dorsal root ganglion (DRG) neurons express the receptors of these pruritogens, MRGPRD and MRGPRX1, respectively, and which cutaneous afferents these pruritogens activate in primate. In situ hybridization studies revealed that MRGPRD and MRGPRX1 are co-expressed in a subpopulation of TRPV1+ human DRG neurons. In electrophysiological recordings in nonhuman primates (Macaca nemestrina), subtypes of polymodal C-fiber nociceptors are preferentially activated by ALA and BAM8-22, with significant overlap. When pruritogens ALA, BAM8-22, and histamine, which activate different subclasses of C-fiber afferents, are administered in combination, human volunteers report itch and nociceptive sensations similar to those induced by a single pruritogen. Our results provide evidence for differences in pruriceptive processing between primates and rodents, and do not support the spatial contrast theory of coding of itch and pain.