Alikaas7484

There are no reliable prospective studies on the effectiveness of topiramate in Bulgarian adult patients with drug-resistant epilepsy.

The aim of the study was to conduct an open, prospective study on various aspects of topiramate (TPM) effectiveness in Bulgarian patients with drug-resistant epilepsy.

The study included patients with epilepsy who attended the Clinic of Neurology at the University Hospital in Plovdiv, Bulgaria. Patients completed diaries for seizure frequency, seizure severity, and adverse events. There were regular documented visits at 3 or 6 months during the first year of TPM treatment and at 6 months afterwards, with a dynamic assessment of seizure fre-quency, severity, adverse events, and EEG recordings.

TPM was used as an add-on treatment in 120 patients (69 males, mean age 37 years). There was a relatively mild and stable dynamic improvement of seizure severity, a satisfactory seizure frequency reduction in 37% of participants, a stable mean seizure fre-quency reduction (47%) frability.

Although ileosigmoid fistulas (ISFs) in Crohn's disease (CD) are rare they can be quite challenging, especially for the inexperienced surgeons. Furthermore, current guidelines offer no clear recommendation regarding the surgical strategy in such cases. A systematic review of the literature to determine the best surgical strategy and a prospective case series are presented herein.

The systematic review was performed according to PRISMA guidelines. A single-center prospective data-base from January 1, 2014 to August 20, 2019 is presented. Age, duration of CD, and the rates of ISF, emergency, preoperative diagnosis, type of surgery, type of stoma, and complications were analyzed and a prospective case series.

Eleven of 69 papers with a total of 505 patients were included in the systematic analysis. The rate of ISF was 3-5% of all CD patients. The combined preoperative detection rate of all modalities was 71%. Primary repair was performed in 42% of the cases; the rate of stoma was 31.5% with a similar propoation of the risk factors. Based on the available literature, no clear recommendation regarding the type of stoma can be made.

There is some evidence suggesting an association between cerebrovascular diseases and the development of depression on the one hand, and between depression and post-stroke recovery on the other. Post-stroke depression can occur in the early post-stroke period or in the later stages of recovery (over 9 months after the incident).

To find a connection between stroke and the development of anxiety and depression in the early period after the development of neurological deficit and to evaluate several scales for their potential usefulness in the screening of post-stroke patients for early signs of depression and anxiety.

We conducted a study on the presence of depression in 117 patients, divided into 2 groups 73 of these patients were admitted due to ischemic stroke, while the other 44 were controls matching the patients in age, sex and education status. The inclusion and exclusion criteria were defined clearly. We included patients that consented to undergo psychiatric evaluation be-tween 24 hours and 7 days after the onset of neurological symptoms. Both groups were assessed by the Montgomery-Asberg Depression Rating Scale (MADRS), Hamilton Anxiety Rating Scale (HAM-A), Hospital Anxiety and Depression Scale - Depression Subscale and Combined Scale (HADS-D, HADS-T).

On evaluation with HADS-D we noted the largest difference between the two groups with a very high statistical significance and a medium effect size (7.92±4.44 points vs. 4.86±4.27 points for the control group, p<0.001, r= -0.417). Anxiety and depressive symp-toms were found also with MADRS and HAM-A.

Anxiety and depressive symptoms were found in the early post-stroke period. MADRS, HADS-D, and HAM-A are suf-ficiently specific and sensitive in the evaluation of post-stroke anxiety and depression.

Anxiety and depressive symptoms were found in the early post-stroke period. MADRS, HADS-D, and HAM-A are suf-ficiently specific and sensitive in the evaluation of post-stroke anxiety and depression.

Obtaining qualitative, sufficient material for the diagnosis of malignancies in cases with normal endoscopic findings in patients with suspected lung cancer and hilar and mediastinal lymphadenopathy is challenging.

Endobronchial ultrasound (EBUS) was used to control a transbronchial needle biopsy (ТBNA) for the first time in our country. From 2015 to 2018, TBNA with a convex probe EBUS was performed on 57 patients [41 men, 16 women, mean age 56.10 (range 37-77 years)] with mediastinal lesions found on CT scan. We used the Hitachi Aloka - ProSound Alpha 7 and BF-UC180F (Olympus) 21G and 22G needles Ultrasound System. In 22 of the cases, we performed a biopsy of hilum lesions (9 on the left and 13 on the right), in 13 - of subcarinal lesions, and in 4 - of lesions located on the right paratracheal lymphatic chain.

EBUS-TBNA confirmed lung cancer in 48 patients (84.2%). AZD9668 order In 33 of them, it was non-small cell lung cancer spinocellular in 13 cases and adenocarcinoma in 17 cases; three cases were without accuraThe results could be improved with training and experience.Fatigue and exhaustion are considered to be the most common complaints of patients with cancer during treatment and upon its completion. The manifestations of fatigue can be physical, cognitive, and emotional. The exact determinants of fatigue, however, are yet unknown. An initial literature review was conducted. Four reference databases were searched (MEDLINE, ELSEVIER - Science Direct, ELSEVIER - SCOPUS, Springer). The initial search yielded 430 articles. We included references consistent with the study design, pub-lished between 1993 and 2017, and written in English or German. The 48 remaining articles were assessed for relevance to the area by visually examining their titles for keywords cancer-related fatigue, assesment, management. Cancer-related fatigue in cancer patients during treatment and in survivors is estimated to have a prevalence in the range of 58% to 90%. This report is a review of the literature relevant to the problem of fatigue in patients with oncological diseases - causes, prevalence, and impact on the lives of affected patients, proposing guidelines for assessment and management.