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Undernutrition was more likely among widowed patients (AOR = 1.7, 95% CI, 1.03-2.79), patients with no access to water supply (AOR = 1.69, 95% CI, 1.16-2.47) and patients in the WHO clinical stage of three (AOR = 2.0, 95% CI, 1.33-2.97) and four (AOR = 3.0, 95% CI, 1.74-5.07). Moreover, the odds of undernutrition was more likely among patients with CD4 cell count of less then 200 cells/mm3 (AOR = 2.0, 95% CI, 1.38-2.47) and patients with a functional status of bedridden (AOR = 3.6, 95% CI, 1.55-8.35) and ambulatory (AOR = 2.4, 95% CI, 1.66-3.51), respectively. CONCLUSION Both undernutrition and overweight or obesity were prevalent among HIV/AIDS patients in Jimma Medical Center, Ethiopia. Undernutrition was significantly associated with clinical outcome of patients. Hence, nutritional assessment, care and support should be strengthened. Critical identification of malnourished patients and prompt interventions should be undertaken.Acute respiratory tract infections (ARTI), including the common cold, pharyngitis, sinusitis, otitis media, bronchiolitis and pneumonia are the most common diagnoses among patients seeking medical care in western countries, and account for most antibiotic prescriptions. While a confirmed and fast ARTI diagnosis is key for antibiotic prescribing, empiric antimicrobial treatment remains common, because viral symptoms are often clinically similar and difficult to distinguish from those caused by bacteria. https://www.selleckchem.com/products/baf312-siponimod.html As a result, inappropriate antibiotic prescriptions are high and in certain settings likely higher than the commonly estimated 30%. The QIAstat Respiratory Panel® assay (QIAstat RP) is a multiplexed in vitro diagnostics test for the rapid simultaneous detection of 21 pathogens directly from respiratory samples, including human mastadenovirus A-G, primate bocaparvovirus 1+2, human coronavirus (HKU1, NL63, OC43, 229E), human metapneumovirus A/B, rhinovirus/enterovirus, influenza A virus (no subtype, subtype H1, H1N1/2009, H3), influenza B virus, human respirovirus 1+3, human orthorubulavirus 2+4, human orthopneumovirus, Bordetella pertussis, Chlamydia pneumoniae, Mycoplasma pneumoniae and Legionella pneumophila. We describe the first multicenter study of 445 respiratory samples, collected through the 2016-2017 and 2018 respiratory seasons, with performance compared against BioFire FilmArray RP v1.7 and discrepancy testing by Seegene Allplex RP. The QIAstat RP demonstrated a positive percentage of agreement of 98.0% (95% CI 96.0-99.1%) and a negative percentage agreement of 99.8% (95% CI 99.6-99.9%). With use of this comprehensive and rapid test, improved patient outcomes and antimicrobial stewardship may potentially be achieved.Tacrolimus (TAC) is the cornerstone of immunosuppressive therapy in liver transplantation. This study aimed at elucidating the interplay between pharmacogenetic determinants of TAC whole blood and intracellular exposures as well as the pharmacokinetic-pharmacodynamic relationship of TAC in both compartments. Complete pharmacokinetic profiles (Predose, and 20 min, 40 min, 1h, 2h, 3h, 4h, 6h, 8h, 12h post drug intake) of twice daily TAC in whole blood and peripheral blood mononuclear cells (PBMC) were collected in 32 liver transplanted patients in the first ten days post transplantation. A non-parametric population pharmacokinetic model was applied to explore TAC pharmacokinetics in blood and PBMC. Concurrently, calcineurin activity was measured in PBMC. Influence of donor and recipient genetic polymorphisms of ABCB1, CYP3A4 and CYP3A5 on TAC exposure was assessed. Recipient ABCB1 polymorphisms 1199G>A could influence TAC whole blood and intracellular exposure (p less then 0.05). No association was found between CYP3A4 or CYP3A5 genotypes and TAC whole blood or intracellular concentrations. Finally, intra-PBMC calcineurin activity appeared incompletely inhibited by TAC and less than 50% of patients were expected to achieve intracellular IC50 concentration (100 pg/millions of cells) at therapeutic whole blood concentration (i.e. 4-10 ng/mL). Together, these data suggest that personalized medicine regarding TAC therapy might be optimized by ABCB1 pharmacogenetic biomarkers and by monitoring intracellular concentration whereas the relationship between intracellular TAC exposure and pharmacodynamics biomarkers more specific than calcineurin activity should be further investigated.We describe a new complex burrow system produced by geomyids in southern Mexico. Yaviichnus inyooensis igen. isp. nov. is composed of main large chambers near the top of the paleosol, from which shafts showing different morphologies and orientations radiate, some of them ending in or connected to small deeper chambers. Gregorymys spp. is proposed as the producer based on its fossorial habits, abundance in the outcrops, presence of remains inside the burrows, and paired grooves in the walls, which are compatible with the traces of geomyid incisors. The complexity of these burrows attests to an extended underground life that would have been triggered by semiarid to arid conditions. Morphological complexity also suggests that the burrows were excavated and inhabited by more than one individual, indicating that Oligocene Gregorymys of southern Mexico would be a unique gregarious geomyid.Previous studies on joint kinetics during track and field block starts have been limited to lower-limb sagittal kinetics; however, we hypothesised that lumbopelvic extensors, lateral flexors, and hip abductors also act as substantial energy generators. The present study aimed to examine the three-dimensional lumbo-pelvic-hip kinetics to better understand the generation of mechanical energy during a block start. 3D kinematic and force data during block starts of 10 m maximal sprinting in 12 male sprinters (personal best in a 100 m sprint, 10.78 ± 0.19 s [range, 10.43-11.01 s]) were captured using a motion capture system and force platform. The three-dimensional lumbo-pelvic-hip kinetics were calculated. The peak lumbosacral extension torque (3.64 ± 0.39 Nm/kg) was significantly larger than any other lower-limb and lumbosacral torques ( less then 3.0 Nm/kg). It was suggested that large lumbopelvic extension torques are needed during the block start to anchor the pelvis by cancelling out both hip extension torques acting on the pelvis, leading to hip extensor-induced thigh sagittal rotations rather than pelvic posterior tilt.