Brantleylauridsen0992

There is accruing evidence of cerebellar abnormalities in individuals with schizophrenia as measured by performance on a variety of tasks believed to be dependent on cerebellar integrity, including delay eyeblink conditioning. There is also evidence of cerebellar dysfunction on a neural level in schizophrenia from both task-based and resting state neuroimaging studies, however few studies have examined cerebellar neural function while the cerebellum is directly recruited in individuals with schizophrenia. In the current pilot study, we examined neural activity during an explicitly cerebellar task in individuals with schizophrenia or schizoaffective disorder and non-psychiatric controls. Participants underwent delay eyeblink conditioning during fMRI. Results indicated eyeblink conditioning impairment in patients as evidenced by a group by time interaction for conditioned responses. A significant cluster of cerebellar activation was present in controls but not patients during the first half of conditioning; there were no significant differences in activation between groups. An ROI analysis focused on the cerebellum in patients revealed two significant clusters that were inversely associated with negative symptom severity. These results are broadly consistent with the theory of cognitive dysmetria, wherein cerebellar abnormalities are theorized to contribute to motor as well as cognitive and affective disturbances in schizophrenia.Global warming has had an unprecedented impact on environmental changes and thus human life in mid-high latitude regions. As one of the areas most affected by global warming, Northeast China has suffered from a series of ecological crises, including warming-induced water deficits, permafrost thaw, and extended growing seasons. The change in annual average temperature (annual T) variations in Northeast China since the Industrial Revolution are still not fully understood, mainly because of the lack of long-term instrumental data and high-resolution annual T reconstructions. Here, we present the first annual T reconstruction (r = -0.683, p less then .001, n = 60) for 1818-2012 in Northeast China, which may also be the first temperature reconstruction based on tree-ring δ18O in China. The reconstruction is significantly related to temperature variations over mid-high latitude Eurasia and agree (p less then .01) with several long-term hydroclimatic reconstructions in the surrounding area. When the internal variability in the reconstruction was high, the decadal to multidecadal cycles were significant. click here Further analysis found that the reconstruction was mainly affected by the East Asian Summer Monsoon (EASM) and North Atlantic Oscillation (NAO). The reconstruction was significantly negatively correlated with several time series of annual T in the Northern Hemisphere, which showed that there is a substantial difference in annual T between Northeast China and other regions of the Northern Hemisphere. The difference mainly existed before the 1950s. From the 1850s to the 1950s, the annual T in Northeast China decreased slightly. However, extreme warming began in the 1950s in Northeast China, and this warming has been unprecedented during the past two centuries. If the warming trend since the 1950s continues, then it will lead to devastating disasters to forest and permafrost ecosystems in Northeast China.In Europe, 25% of groundwater has poor chemical status. One of the main stressors is agriculture, with nitrates and plant protection products (PPPs) causing failure in 18% and 6.5%, respectively, of groundwater bodies (by area). EU legislation for the placement of the PPPs on the market is one of the most stringent in the world. However, recent monitoring studies in hilly vineyards of Tidone Valley, north-west of Italy, show presence of PPPs used for grapevine cultivation in 15 out of 26 groundwater wells monitored, at values above the Environment Quality Standard (EQS) for groundwater (0.1 μg/L). However, no information about the contamination sources are available. Therefore, the objective of the present work is to evaluate the groundwater contamination sources by PPPs, in a small catchment with intensive viticulture, by collecting and integrating monitoring data, sub-surface water movement data and territorial characteristics. The results show that in wells used for PPP's mixture preparation and sprayer washing located at the top of hilly vineyards, with low slope and no water movement in the surrounding soil, the contamination is most likely from point sources. On the contrary, for wells located in a fenced area at the bottom of the hill, far away from vineyards and being used for drinking water production, the contamination is most likely from diffuse sources. Our results were used to raise awareness on groundwater contamination from PPPs among farmers in the study area; moreover a waterproof platform for sprayers washing, equipped with wastewater recovery and disposal system, able to avoid point-source contamination, was implemented in a local demonstration farm. Several demonstration activities were then organised with the farmers of the entire Valley in order to show its functionality and promote its diffuse use.

The aim of the article was to identify the top 50 cited articles in the journal of Photodiagnosis and Photodynamic Therapy during 2004-2019.

The online search was conducted on Scopus database to retrieve all the articles published during 2004-2019 in the journal of Photodiagnosis and Photodynamic Therapy. The papers were identified and ranked as per the citation counts >42. Additionally the authors; institute and country of origin; type of study and availability of funding in these highly cited articles was identified. VOS viewer software was used to analyze the occurrence of most commonly used keywords by the authors.

Majority of the highly cited studies published during last 15 years were literature reviews (n = 34) followed by the qualitative/quantitative studies (n = 15). The largest number of articles published were single nations without any collaborations (n = 45). The institutes publishing highest number of top cited articles included Massachusetts General Hospital, East Carolina University, 21 st Century Oncology, The Norwegian Radium Hospital and Trinity College Dublin.