Kleinbuch9733
Girls did not differ on AOC but had a later AOD than boys. Higher verbal IQ was associated with later AOD more strongly in girls than boys. Regarding time-related changes, average AOC and AOD increased across the study period, more strongly for girls.
Results support that sex is a key factor underlying delays in ASD identification and highlight the urgent need to improve diagnostic practices among girls. Limitations and implications for improving the diagnostic process are discussed.
Results support that sex is a key factor underlying delays in ASD identification and highlight the urgent need to improve diagnostic practices among girls. Limitations and implications for improving the diagnostic process are discussed.Abbreviations ASD=autism spectrum disorder; IQ=intelligence quotient; AOC=parental report of age of first concern; AOD=age of diagnosis.Programmatic assessment and program evaluation are both important within competency-based medical education (CBME) programs. Given this importance, there is value in evaluating programmatic assessment as well as using the information collected in programmatic assessment for the evaluation of CBME programs. In order to help facilitate these two activities, this paper distinguishes between programmatic assessment and program evaluation as well as highlights the connections between them. selleck In doing so, it shows that programmatic assessment and program evaluation, when employed appropriately, can complement each other and contribute to the overall effectiveness of CBME programs.
To analyze the morphological and functional findings using microperimetry and optical coherence tomography angiography (OCTA) in patients with acute posterior multifocal placoid pigment epitheliopathy (APMPPE).
This retrospective observational case series included four eyes of two patients with APMPPE. Best-corrected visual acuity range was from 20/20 to 20/250. Microperimetry and OCTA evaluation were obtained in the acute and healed phase. The OCTA images of the choriocapillaris were superimposed on the microperimetry map at the last visit.
The retinal sensitivity improved between the baseline and the last visit in three out of the four eyes. At resolution phase, OCTA revealed zones with choriocapillaris flow deficit, which were associated with points of reduced retinal sensitivity.
Microperimetry allows for a better evaluation of the extent of the unhealed functional defect in eyes with AMPPE. The multimodal imaging showed that structural and functional findings were associated in the resolution phase.
Microperimetry allows for a better evaluation of the extent of the unhealed functional defect in eyes with AMPPE. The multimodal imaging showed that structural and functional findings were associated in the resolution phase.
Blood flow restriction therapy (BFRT) has been increasingly applied to improve athletic performance and injury recovery. Validation of BFRT has lagged behind commercialization, and currently the mechanism by which this therapy acts is unknown. BFRT is one type of ischemic therapy, which involves exercising with blood flow restriction. Repetitive restriction of muscle blood flow (RRMBF) is another ischemic therapy type, which does not include exercise.
The purpose was to develop a rat model of ischemic therapy, characterize changes to muscle contractility, and evaluate local and systemic biochemical and histologic responses of 2 ischemic therapy types. We hypothesized that ischemic therapy would improve muscle mass and strength as compared with the control group.
Controlled laboratory study.
Four groups of 10 Sprague-Dawley rats were established control, stimulation, RRMBF, and BFRT. One hindlimb of each subject underwent 8 treatment sessions over 4 weeks. To simulate exercise, the stimulation group unas eliciting elevated GH levels as compared with the other groups (
< .001).
Ischemic therapy did not induce gains in muscle mass, contractility strength, fiber cross-sectional area, or satellite cell density locally or systemically in this model, although the RRMBF group did have elevated GH levels on ELISA.
This animal model does not support ischemic therapy as a method to improve muscle mass, function, or satellite cell density.
This animal model does not support ischemic therapy as a method to improve muscle mass, function, or satellite cell density.
Efforts are being made to treat rotator cuff tears (RCTs) that exhibit poor healing and high retear rates. Tendon-to-bone healing using mesenchymal stem cells is being explored, but research is needed to establish effective delivery options.
To evaluate the effects of an adipose-derived stem cell (ADSC) sheet on mesenchymal stem cell delivery for tendon-to-bone healing of a chronic RCT in rats and to demonstrate that ADSC sheets enhance tendon-to-bone healing.
Controlled laboratory study.
Mesenchymal stem cells were obtained from rat adipose tissue, and a cell sheet was prepared using a temperature-responsive dish. To evaluate the efficacy of stem cells produced in a sheet for the lesion, the experiment was conducted with 3 groups repair group, cell sheet transplantation after repair group, and cell sheet-only group. Histological, biomechanical, and micro-computed tomography (micro-CT) results were compared among the groups.
Hematoxylin and eosin staining for histomorphological analysis revealed thaepairing RCTs, which are common sports injuries.
This laboratory study provides evidence that ADSCs are effective in repairing RCTs, which are common sports injuries.The paper is concerned with simulation of the periodontal ligament response to force in the initial phase of orthodontic tooth movement. This is based on two previous investigations, a in vitro experiment with specimens of porcine mandibular premolars and a in vivo experiment on human upper first incisors. For the curve fit of the in vitro experiment a model function, assuming viscoelasticity, was introduced. The viscoelastic model function was augmented by a ramp rise time term, to account for observed dependence of the response on actuator velocity, and a previous load history term, to account for the effect of the previous tests on the current test. The correlation coefficient of a curve fit for all tests grouped together was R 2 = 0.98 . Next, a curve fit of the in vivo experiment was done. Good correlation was found for a simplified model function, without viscoelastic term ( R 2 = 0.96 ). For both tests, in vitro and in vivo, the ramp rise time term improved correlation. A finite element model of the specimen of the in vitro experiment was created.