Trevinohougaard0227

We aimed to perform an economic analysis and compare the clinical outcomes between inpatient and short-stay designation total ankle replacement (TAR).

We performed a retrospective study on 178 consecutive patients undergoing primary inpatient versus short-stay designation TAR during the 2016 and 2017 fiscal years. Sunitinib Patient demographics, concomitant procedures, perioperative complications, patient-reported outcomes, and perioperative costs were collected.

The mean age of our cohort was 62.5 ± 9.6 years (range, 30-88 years), with a significant difference in age (64.1 vs 58.5 years) (

= .005) and Charlson Comorbidity Index (3.3 ± 1.9 vs 2.3 ± 1.4;

= .002) for the inpatient and short-stay designation groups, respectively. At a mean follow-up of 29.6 ± 11.8 months (range, 12-52.3 months), there was no difference in complications between groups (

= .97). The inpatient designation TAR group had a worse baseline Short Musculoskeletal Functional Assessment (SMFA) function score (76.1; 95% CI, 70.5-81.6) than the short-stay designation TAR group (63.9; 95% CI, 52.5-75.3) while achieving similar final postoperative SMFA function scores for the inpatient (55.2; 95% CI, 51.1-59.2) and short-stay (56.2; 95% CI, 48.2-64.2) designation TAR groups (

> .05). However, the inpatient designation TAR group showed a significantly greater mean improvement in SMFA function score (20.9; 95% CI, 19.4-22.4) compared with the short-stay designation TAR group (7.7; 95% CI, 3.7-11.1) (

= .0442). The total direct cost was significantly higher for the inpatient designation group ($15 340) than the short-stay designation group ($13 002) (

< .001).

While inpatient designation TARs were more comorbid, short-stay designation TARs were associated with a 15.5% reduction in perioperative costs, comparable complication rates, and similar final postoperative patient-reported outcome scores compared with inpatient TARs.

Level III, retrospective comparative study.

Level III, retrospective comparative study.

A retrospective study.

Intraoperative skull-skeletal traction (ISST) facilitates the surgical scoliosis correction, but it is also associated with neurological risk. The objective of the present study was to investigate the impact of various traction weights on neurophysiological change and curve correction in surgery for adolescent idiopathic scoliosis (AIS).

A retrospective review of a consecutive series of posterior spinal fusions for AIS patients undergoing corrections with the use of ISST by 2 surgeons in one institution was performed. Intraoperative prone, post-traction radiographs were performed on all cases. The cases were divided into 2 groups, high and low traction weights, based on whether the weight used was ≥35% or <35% of body weight. The frequency of neurophysiological changes and the curve correction were compared between the 2 groups.

The intraoperative correction magnitudes by ISST were significantly larger in the high ISST group than in the low ISST group (35° vs 26°,

< .001). Changes in motor-evoked potential (MEP) were more frequently observed in the high ISST group (47% vs 26%,

= .049). A multivariate analysis showed that high ISST was associated with 3 times higher risk of MEP change (95% confidence interval = 1.1-8.0,

= .03) and higher final postoperative correction rates (68% vs 60%,

= .001).

The high ISST for AIS was associated with increased intraoperative and ultimate curve corrections, and potentially facilitated better final correction. However, the high weight group was associated with an increased frequency of intraoperative MEP changes.

The high ISST for AIS was associated with increased intraoperative and ultimate curve corrections, and potentially facilitated better final correction. However, the high weight group was associated with an increased frequency of intraoperative MEP changes.1. In this study, hyperspectral imaging was evaluated for its usefulness to predict quality traits and grading of intact chicken breast fillets. 2. Lightness of colour (L*) and pH of the fillets were measured as quality traits, and samples were then selected and graded to three different quality categories, i.e., dark, firm and dry (DFD), normal (NORM), and pale, soft and exudative (PSE) based on these two quality traits. Based on the prediction performance of full wavelength partial least square regression (PLSR) models, the spectral range of visible and near-infrared (Vis-NIR) was more suitable for the evaluation of quality traits and grading than the range of near-infrared (NIR). Key wavelengths of each quality trait and grade value were selected by the regression coefficient (RC) method. 3. The new key wavelength PLSR models showed good predictive performances (Rp = 0.85 and RMSEp = 2.18 for L*, Rp = 0.84, and RMSEp = 0.13 for pH, and Rp = 0.80 and RMSEp = 0.44 for quality grading). The classification accuracy for grades was 85.71% (calibration set) and 81.82% (prediction set), respectively. Finally, distribution maps showed that quality traits and grades of samples were able to be visualised. 4. These results suggested that hyperspectral imaging has the potential for quality prediction of fresh chicken meat.After the increasing number of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections all over the world, researchers and clinicians are struggling to find a vaccine or innovative therapeutic strategies to treat this viral infection. The severe acute respiratory syndrome coronavirus infection that occurred in 2002, Middle East respiratory syndrome (MERS) and other more common infectious diseases such as hepatitis C virus, led to the discovery of many RNA-based drugs. Among them, siRNAs and antisense locked nucleic acids have been demonstrated to have effective antiviral effects both in animal models and humans. Owing to the high genomic homology of SARS-CoV-2 and severe acute respiratory syndrome coronavirus (80-82%) the use of these molecules could be employed successfully also to target this emerging coronavirus. Trying to translate this approach to treat COVID-19, we analyzed the common structural features of viral 5'UTR regions that can be targeted by noncoding RNAs and we also identified miRNAs binding sites suitable for designing RNA-based drugs to be employed successfully against SARS-CoV-2.