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94 μg/ml). Cytotoxic effect of SMM was also strongest towards MCF-7 cells whilst the least cytotoxic sample was SGM (IC50 > 1000 μg/ml). SMM had the highest antioxidant percentage (EC50 = 1.05 mg/ml). The increasing order of antioxidant percentage among the five herbal mixtures is SMM > SMH > STT > STF > SGM. The herbal mixtures may be potential sources of toxic agents to host cells. Therefore, further toxicity studies must be performed to safeguard health of the public. Interestingly, cytotoxicities exhibited by SMM and SGM suggest the presence of anticancer constituents in them which warrant further studies. Copyright © 2020 Isaac Dadzie et al.Objective To compare the effect of sutureless versus multiple sutures technique on postoperative variables such as pain, swelling, and trismus after surgical removal of the third molar in Nepalese subpopulation. Materials and Methods. Forty-eight patients were equally grouped into multiple sutures (group 1) and sutureless (group 2) groups using a computer-generated random table. The same operator performed all the surgical procedures. Postoperative variables such as pain, swelling, and trismus were measured by a single concealed observer using a 10 cm Numerical Rating Scale (NRS), flexible plastic measuring tape, and vernier caliper preoperatively and on 1st, 2nd, and 7th postoperative days. Results This study showed significantly more swelling measured from the gonion to lateral canthus in group 1 than in group 2 on all postoperative periods (P less then 0.05). The mean NRS score was significantly higher in group 1 on the 1st postoperative day (P less then 0.05). The mean NRS score was significantly higher in group 1 on the 1st postoperative day (. Conclusion Our results support the use of sutureless technique after third molar surgery to minimize postoperative morbidity and the overall operative time and reduce the cost within the Nepalese subpopulation. Copyright © 2020 Arun Kr. Mahat et al.The root canal system must be obturated using a hermetic seal to prevent the penetration of microorganisms and bacterial toxins into the endodontic system. The principles of adhesive dentistry have been increasingly used in endodontics. In fact, resin-based sealers are increasingly used. The objective of this study was to evaluate, in vitro, the sealing ability of resin cement in comparison with calcium hydroxide-based cement. Materials and Methods. Eighty root canals were prepared with the Tilos system and were randomly divided into four groups according to the filling material. The best combination was evaluated on the basis of its sealing ability. The dye infiltration degree was evaluated using both a stereomicroscope after diaphanization and the dye rise test. Results. A significant difference was observed between the four obturation systems with regard to the number of infiltrated walls (p=0.014) and the infiltration depth (p=0.025). The group of teeth obturated with EndoREZ® and EndoREZ® gutta cones differ significantly from the group obturated with EndoREZ® cement and gutta-percha cones in terms of apical sealing (p=0.011). A significant difference was also observed between the group of teeth obturated using EndoREZ® gutta cones and EndoREZ® cement and the group of teeth obturated with EndoREZ® cement (p=0.026). Conclusion. When used with EndoREZ® gutta cones, EndoREZ® cement showed the best sealing ability, particularly in the apical region. When used with gutta-percha cones, Acroseal and EndoREZ® cements exhibited similar sealing abilities. Copyright © 2020 Amira Kikly et al.First identified as a developmental gene, HOXB9 is also known to be involved in tumor biological processes, and its aberrant expression correlates with poor prognosis of various cancers. In this study, we isolated a homeodomain-less, novel HOXB9 variant (HOXB9v) from human breast cancer cell line-derived mRNA. We confirmed that the novel variant was produced from variationless HOXB9 genomic DNA. RT-PCR of mRNA isolated from clinical samples and reanalysis of publicly available RNA-seq data proved that the new transcript is frequently expressed in human breast cancer. Exogenous HOXB9v expression significantly enhanced the proliferation of breast cancer cells, and gene ontology analysis indicated that apoptotic signaling was suppressed in these cells. Considering that HOXB9v lacks key domains of homeobox proteins, its behavior could be completely different from that of the previously described variationless HOXB9. Because none of the previous studies on HOXB9 have considered the presence of HOXB9v, further research analyzing the two transcripts individually is warranted to re-evaluate the true role of HOXB9 in cancer. Copyright © 2020 Ayako Nakashoji et al.Background The aim of this study is to evaluate the chemopreventive and chemotherapeutic activities of Ficus deltoidea (FD) in an animal model induced for oral cancer using 4-nitroquinoline-1-oxide (4NQO). Methods Male Sprague-Dawley (SD) rats were randomized into six groups (n = 7 per group) Group 1 (untreated group); Group 2 (control cancer group) received 4NQO only for 8 weeks in their drinking water; Groups 3 and 4 (chemopreventive) received 4NQO for 8 weeks and were simultaneously treated with FD extract at 250 and 500 mg/kg, respectively, by oral gavage; Groups 5 and 6 (chemotherapeutic) received 4NQO for 8 weeks followed by the administration of FD extract at 250 and 500 mg/kg, respectively, for another 10 weeks. The incidence of oral cancer was microscopically evaluated. Moreover, immunohistochemical expression was analysed in tongue specimens using an image analyser computer system, while the RT2 profiler PCR array method was employed for gene expression analysis. Results The results of the present s4NQO, thus having the potential to be developed as chemopreventive and chemotherapeutic agents. Copyright © 2020 May Al-koshab et al.Saliva biomarkers using reagent-free biophotonic technology have not been investigated as a strategy for early detection of breast cancer (BC). this website The attenuated total reflection-Fourier transform infrared (ATR-FTIR) spectroscopy has been proposed as a promising tool for disease diagnosis. However, its utilization in cancer is still incipient, and currently saliva has not been used for BC screening. We have applied ATR-FTIR onto saliva from patients with breast cancer, benign breast disease, and healthy matched controls to investigate its potential use in BC diagnosis. Several salivary vibrational modes have been identified in original and second-derivative spectra. The absorbance levels at wavenumber 1041 cm-1 were significantly higher (p less then 0.05) in saliva of breast cancer patients compared with those of benign patients, and the ROC curve analysis of this peak showed a reasonable accuracy to discriminate breast cancer from benign and control patients. The 1433-1302.9 cm-1 band area was significantly higher (p less then 0.