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Restoring miR-30e or silencing SOX9 energized cell viability and inhibited apoptosis of H/R-treated cardiomyocytes. Down-regulating SOX9 reversed the effects of miR-30e down-regulation on myocardial injury, ventricular remodeling, cardiomyocyte damage and apoptosis in MI/RI.

It is concluded that miR-30e elevation alleviated cardiac function damage and promoted ventricular remodeling via SOX9 repression.

It is concluded that miR-30e elevation alleviated cardiac function damage and promoted ventricular remodeling via SOX9 repression.Fe/C composite is emerging as a promising nanoscale zero-valent iron (nZVI) based material for wastewater treatment to counteract the limitations of nZVI, while its preparation method, structure-activity relationship, and working mechanisms and conditions still need to be studied. In this study, Fe/C composites derived from iron-crosslinked alginate was successfully achieved via high temperature pyrolysis. Ferric ions were only transformed into Fe3O4/γ-Fe2O3 at low pyrolysis temperature (≤500 °C), whereas Fe0/Fe3C became the primary Fe species with the formation of graphitic carbon at elevated pyrolysis temperature (≥700 °C). Fe/C composites from higher pyrolysis temperature presented better performance in atrazine (ATZ) removal, and the optimal pyrolysis temperature was 800 °C (Fe/C-800). Batch experiments showed that the removal kinetics of ATZ (10 mg L-1) by Fe/C-800 (0.2 g L-1) followed pseudo-second-order model, and 24-h ATZ removal efficiency maintained at 93.5 ± 1.0% within pH 3-9. The adsorption by the graphitic carbon phase of Fe/C-800 was the principal contributor to the pH-independent superior performance in ATZ removal, and the Langmuir model fitted adsorption capacity was 64.8 mg g-1 at pH 6. Although the carbon-phase adsorbed ATZ was basically unavailable for degradation, Fe0/Fe3C-mediated ATZ degradation contributed to the great reactivity of Fe/C-800 at pH 3. Fe0/Fe3C in Fe/C-800 was more efficient for ATZ degradation than commercial nZVI, and oxidative dealkylation by Fe0/Fe3C mediated Fenton reaction was the predominant ATZ degradation pathway rather than reductive dechlorination. Moreover, the produced ATZ degradation intermediates could be further adsorbed by Fe/C-800, mitigating potential secondary pollution. Thus, iron-crosslinked alginate derived Fe/C composites can be an excellent alternative for nZVI in organics-polluted water treatment with great reactivity and wide pH applicability.Electric vehicles (EVs) are promoted in recent years as an effective way in alleviating the air pollution caused by tailpipe emissions. However, the pollutants derived from EVs are unheeded. EVs rely on electricity to provide power, and thus their related pollution is transferred to the power plants, which gives rise to the environmental and health pressure to the adjacent regions. In this paper, the transfer of EV-attributed PM2.5, SO2, and NOx inhalations in China are studied. RBPJ Inhibitor-1 nmr Then by comparing the inhalations versus traffic accessibility among the impacted municipalities, this study sheds light on the environmental injustice lying in the mismatch between pollutant inhalations and traffic accessibility. The results reveal that compared with Shanghai and Shenzhen, the promotion of EVs in Beijing triggers higher pollutant inhalations to its surrounding municipalities. North China Power Grid undertakes 715.62 g PM2.5 inhalation in total, which is 2.51 and 3.20 times higher than the East China Power Grid and the China Southern Power Grid, respectively. The number of municipalities with lower traffic accessibility while higher pollutant inhalation is 8,8, and 17 in North China Power Grid, East China Power Grid, and China Southern Power Grid respectively, indicating conspicuous environmental injustice resulted from the promotion of EVs.Effects of sewage sludge-derived biochar and its precursor on the accumulation of metals (Cd, Cu, Pb and Zn) in soil and their uptake by plants in a 1-year field experiment involving corn-radish rotation were comparatively studied. The human health risks were assessed, and the safe application period of biochar were estimated. The application of biochar, compares to sewage sludge, significantly enhanced the radish yield (p less then 0.05; not corn yield) and significantly reduced the accumulation of metals in both plants (p less then 0.05), especially the annual application at ≤15 t ha-1. The hazard quotient analyses of the metals showed there were no health risks to humans (Hazard Index less then 1) in consuming the edible parts of the both plants. The application of sewage sludge at ≥15 t ha-1 resulted in Cd in radish exceeded the threshold for foodstuffs set by China (0.1 mg kg-1). The total contents of Cd, Cu, Pb and Zn in soil increased gradually as the application of sewage sludge or its biochar increased from 7.5 t ha-1 to 30 t ha-1. More metals were found to be introduced to soil by the land application of biochar than by its precursor at the same doses, because the metals were concentrated in biochar during the preparation process. The contamination risk assessment of soil based on the geo-accumulation index, the contamination factor and the pollution load index suggested the application of biochar on farmland should less then 15 t ha-1. Therefore, taking into account the yield of and metal concentrations in the radish and corn plants and the contamination risks in soil, it is recommended that the continuous safe application period at an application of 7.5 t ha-1 year-1 of biochar should not exceed 15 years, and that of its precursor sewage sludge should not exceed 17 years.In recent decades, there has been growing concern regarding worsening global climate conditions for agricultural production, especially in Mediterranean climate and other semi-arid areas where the scarcity of water is a major problem. The objective of the study was to estimate the long-term evolution (in Spain, over 1922-2016) of the decoupling between crop's water requirements and the green water available, and to analyze the causes of the changes. The FA0-56 methodology was followed to estimate the green water, blue water and water stress of crops, via an explicit territorial distribution, using 0.5o grid cells. We propose a new indicator called Violet Water. This indicator groups together the water stress of the rainfed croplands and the blue water of the irrigated croplands, representing the components of this decoupling. Our results show that crops´ water requirements increased by 21% and violet water by 30% over the study period. The decomposition analysis used to study the drivers of these changes suggests that increasing reference evapotranspiration, caused by global warming, was the major driver triggering the growth of crop water requirements.